ID:HCAR2_HUMAN DESCRIPTION: RecName: Full=Hydroxycarboxylic acid receptor 2; AltName: Full=G-protein coupled receptor 109A; AltName: Full=G-protein coupled receptor HM74A; AltName: Full=Niacin receptor 1; AltName: Full=Nicotinic acid receptor; FUNCTION: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5- methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils. DEVELOPMENTAL STAGE: Expression in neutrophils occurs in the late terminal differentiation phase. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/gpr109a/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on Q8TDS4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001781 neutrophil apoptotic process GO:0006915 apoptotic process GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0033031 positive regulation of neutrophil apoptotic process GO:0050995 negative regulation of lipid catabolic process GO:0070165 positive regulation of adiponectin secretion
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
