Human Gene HEATR5B (ENST00000233099.6_7) from GENCODE V47lift37

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Description: HEAT repeat containing 5B (from RefSeq NM_019024.3)
Gencode Transcript: ENST00000233099.6_7
Gencode Gene: ENSG00000008869.12_13
Transcript (Including UTRs)
Position: hg19 chr2:37,208,038-37,311,515 Size: 103,478 Total Exon Count: 36 Strand: -
Coding Region
Position: hg19 chr2:37,208,633-37,310,557 Size: 101,925 Coding Exon Count: 35

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:37,208,038-37,311,515)			mRNA (may differ from genome)		Protein (2071 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: HTR5B_HUMAN DESCRIPTION: RecName: Full=HEAT repeat-containing protein 5B; SIMILARITY: Belongs to the HEATR5 family. SIMILARITY: Contains 3 HEAT repeats. SEQUENCE CAUTION: Sequence=BAA91733.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D003993 Dibutyl Phthalate D004137 Dinitrochlorobenzene D005054 Eugenol D006830 Hydralazine D007545 Isoproterenol D018817 N-Methyl-3,4-methylenedioxyamphetamine D014635 Valproic Acid C044887 beta-methylcholine C045651 epigallocatechin gallate more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 9.27 RPKM in Brain - Cerebellar Hemisphere Total median expression: 308.07 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-41.00	126	-0.325	Picture	PostScript	Text
3' UTR	-107.80	595	-0.181	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR016024 - ARM-type_fold

SCOP Domains:
48371 - ARM repeat
48431 - Lipovitellin-phosvitin complex, superhelical domain

ModBase Predicted Comparative 3D Structure on Q9P2D3


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Cellular Component: GO:0016020 membrane

Descriptions from all associated GenBank mRNAs


	AK001513 - Homo sapiens cDNA FLJ10651 fis, clone NT2RP2005868. AB037835 - Homo sapiens mRNA for KIAA1414 protein, partial cds. BX538008 - Homo sapiens mRNA; cDNA DKFZp686B2046 (from clone DKFZp686B2046). FW340042 - Screening. AL832880 - Homo sapiens mRNA; cDNA DKFZp667J243 (from clone DKFZp667J243). AK026928 - Homo sapiens cDNA: FLJ23275 fis, clone HEP02872. BX648805 - Homo sapiens mRNA; cDNA DKFZp686P15184 (from clone DKFZp686P15184). BC150605 - Homo sapiens HEAT repeat containing 5B, mRNA (cDNA clone MGC:183515 IMAGE:9056975), complete cds. LF342138 - JP 2014500723-A/149641: Polycomb-Associated Non-Coding RNAs. JD257108 - Sequence 238132 from Patent EP1572962. LF342139 - JP 2014500723-A/149642: Polycomb-Associated Non-Coding RNAs. JD229108 - Sequence 210132 from Patent EP1572962. MA577715 - JP 2018138019-A/149641: Polycomb-Associated Non-Coding RNAs. MA577716 - JP 2018138019-A/149642: Polycomb-Associated Non-Coding RNAs. BC085607 - Homo sapiens cDNA clone IMAGE:30397365. BC031035 - Homo sapiens, clone IMAGE:4734442, mRNA. AK096637 - Homo sapiens cDNA FLJ39318 fis, clone OCBBF2014089. AK022179 - Homo sapiens cDNA FLJ12117 fis, clone MAMMA1000084. AK093937 - Homo sapiens cDNA FLJ36618 fis, clone TRACH2016533. AX748373 - Sequence 1898 from Patent EP1308459. JD553917 - Sequence 534941 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: B5MDU8, ENST00000233099.1, ENST00000233099.2, ENST00000233099.3, ENST00000233099.4, ENST00000233099.5, HEATR5B , HTR5B_HUMAN, KIAA1414 , NM_019024, p200 , p200a , Q7Z3B2, Q9NVL7, Q9P2D3, uc317dwl.1, uc317dwl.2 UCSC ID: ENST00000233099.6_7 RefSeq Accession: NM_019024.3 Protein: Q9P2D3 (aka HTR5B_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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