ID:HNMT_HUMAN DESCRIPTION: RecName: Full=Histamine N-methyltransferase; Short=HMT; EC=2.1.1.8; FUNCTION: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. CATALYTIC ACTIVITY: S-adenosyl-L-methionine + histamine = S- adenosyl-L-homocysteine + N(tau)-methylhistamine. SUBUNIT: Monomer. SUBCELLULAR LOCATION: Cytoplasm. POLYMORPHISM: Variant Ile-105 has a reduced activity and seems to be linked with a predisposition to asthma. SIMILARITY: Belongs to the methyltransferase superfamily. HNMT family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P50135
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein P50135 (Reactome details) participates in the following event(s):
R-HSA-175993 HNMT transfers CH3 group from AdoMet to Hist R-HSA-2408544 AdoSeMet is converted to AdeSeHCys by MetTrans(1) R-HSA-70921 Histidine catabolism R-HSA-2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-6788656 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism R-HSA-2408522 Selenoamino acid metabolism R-HSA-71291 Metabolism of nitrogenous molecules R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
