ID:SIAL_HUMAN DESCRIPTION: RecName: Full=Bone sialoprotein 2; AltName: Full=Bone sialoprotein II; Short=BSP II; AltName: Full=Cell-binding sialoprotein; AltName: Full=Integrin-binding sialoprotein; Flags: Precursor; FUNCTION: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. SUBCELLULAR LOCATION: Secreted. PTM: N-glycosylated; glycans consist of sialylated and core- fucosylated bi-, tri- and tetraantennary chains. PTM: O-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc. PTM: Sulfated on either Tyr-313 or Tyr-314. MISCELLANEOUS: It is possible that the segments of clustered carboxyl groups mediate the strong binding to hydroxyapatite.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05432 - Bone sialoprotein II (BSP-II)
ModBase Predicted Comparative 3D Structure on P21815
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
