Human Gene IL17RA (ENST00000319363.11_9) from GENCODE V47lift37
  Description: interleukin 17 receptor A, transcript variant 1 (from RefSeq NM_014339.7)
Gencode Transcript: ENST00000319363.11_9
Gencode Gene: ENSG00000177663.15_12
Transcript (Including UTRs)
   Position: hg19 chr22:17,565,890-17,596,583 Size: 30,694 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr22:17,565,982-17,590,710 Size: 24,729 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:17,565,890-17,596,583)mRNA (may differ from genome)Protein (866 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: I17RA_HUMAN
DESCRIPTION: RecName: Full=Interleukin-17 receptor A; Short=IL-17 receptor A; Short=IL-17RA; AltName: Full=CDw217; AltName: CD_antigen=CD217; Flags: Precursor;
FUNCTION: Receptor for IL17A and IL17F. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.
INTERACTION: Q8NFR9:IL17RE; NbExp=2; IntAct=EBI-5591258, EBI-5591275;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).
TISSUE SPECIFICITY: Widely expressed.
PTM: Glycosylated.
DISEASE: Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5) [MIM:613953]. CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
SIMILARITY: Contains 1 SEFIR domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IL17RA
Diseases sorted by gene-association score: immunodeficiency 51* (919), familial candidiasis 5* (500), chronic mucocutaneous candidiasis* (265), adenosine deaminase 2 deficiency (13), nasopharyngitis (11), nasopharyngeal disease (9), stromal keratitis (7), candidiasis (7), cat eye syndrome (5), rheumatoid arthritis (4), opportunistic mycosis (4)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 36.89 RPKM in Whole Blood
Total median expression: 245.90 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -28.5092-0.310 Picture PostScript Text
3' UTR -2294.605873-0.391 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013568 - SEFIR

Pfam Domains:
PF08357 - SEFIR domain
PF16556 - Interleukin-17 receptor, fibronectin-III-like domain 1
PF16578 - Interleukin 17 receptor D

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3JVF - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q96F46
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0030368 interleukin-17 receptor activity

Biological Process:
GO:0007166 cell surface receptor signaling pathway
GO:0032747 positive regulation of interleukin-23 production
GO:0050729 positive regulation of inflammatory response
GO:0050832 defense response to fungus
GO:0071345 cellular response to cytokine stimulus
GO:0071621 granulocyte chemotaxis
GO:0072537 fibroblast activation
GO:0097400 interleukin-17-mediated signaling pathway
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:2000664 positive regulation of interleukin-5 secretion
GO:2000667 positive regulation of interleukin-13 secretion

Cellular Component:
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF212070 - JP 2014500723-A/19573: Polycomb-Associated Non-Coding RNAs.
LF207365 - JP 2014500723-A/14868: Polycomb-Associated Non-Coding RNAs.
BC011624 - Homo sapiens interleukin 17 receptor A, mRNA (cDNA clone MGC:10262 IMAGE:4053746), complete cds.
CT841520 - Homo sapiens IL17R full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.IL17R.V3).
BC012071 - Homo sapiens interleukin 17 receptor A, mRNA (cDNA clone IMAGE:4576024), with apparent retained intron.
U58917 - Homo sapiens IL-17 receptor mRNA, complete cds.
AB527163 - Synthetic construct DNA, clone: pF1KB3719, Homo sapiens IL17RA gene for interleukin 17 receptor A, without stop codon, in Flexi system.
CU013393 - Homo sapiens IL17R, mRNA (cDNA clone IMAGE:100000473), complete cds, without stop codon, in Gateway system.
DQ891962 - Synthetic construct clone IMAGE:100004592; FLH181861.01X; RZPDo839H11136D interleukin 17 receptor A (IL17RA) gene, encodes complete protein.
DQ895152 - Synthetic construct Homo sapiens clone IMAGE:100009612; FLH181857.01L; RZPDo839H11135D interleukin 17 receptor A (IL17RA) gene, encodes complete protein.
CU013105 - Homo sapiens IL17R, mRNA (cDNA clone IMAGE:100000569), complete cds, with stop codon, in Gateway system.
JF305973 - Homo sapiens truncated IL-17RA mRNA, complete cds.
AF021799 - Homo sapiens interleukin 17 receptor-like mRNA sequence.
LF365606 - JP 2014500723-A/173109: Polycomb-Associated Non-Coding RNAs.
KY994064 - Homo sapiens QXBT22 miRNA, complete sequence.
KY994086 - Homo sapiens precursor microRNA QXBT22, complete sequence.
LF365609 - JP 2014500723-A/173112: Polycomb-Associated Non-Coding RNAs.
LF365610 - JP 2014500723-A/173113: Polycomb-Associated Non-Coding RNAs.
JD085904 - Sequence 66928 from Patent EP1572962.
JD442483 - Sequence 423507 from Patent EP1572962.
JD178584 - Sequence 159608 from Patent EP1572962.
JD283539 - Sequence 264563 from Patent EP1572962.
JD188139 - Sequence 169163 from Patent EP1572962.
JD118737 - Sequence 99761 from Patent EP1572962.
JD336022 - Sequence 317046 from Patent EP1572962.
JD470844 - Sequence 451868 from Patent EP1572962.
JD114120 - Sequence 95144 from Patent EP1572962.
JD378327 - Sequence 359351 from Patent EP1572962.
JD413362 - Sequence 394386 from Patent EP1572962.
JD246883 - Sequence 227907 from Patent EP1572962.
JD097906 - Sequence 78930 from Patent EP1572962.
JD138826 - Sequence 119850 from Patent EP1572962.
JD075039 - Sequence 56063 from Patent EP1572962.
JD453650 - Sequence 434674 from Patent EP1572962.
JD533749 - Sequence 514773 from Patent EP1572962.
JD373430 - Sequence 354454 from Patent EP1572962.
JD483577 - Sequence 464601 from Patent EP1572962.
JD138479 - Sequence 119503 from Patent EP1572962.
JD066840 - Sequence 47864 from Patent EP1572962.
JD093116 - Sequence 74140 from Patent EP1572962.
JD561479 - Sequence 542503 from Patent EP1572962.
JD282074 - Sequence 263098 from Patent EP1572962.
JD270216 - Sequence 251240 from Patent EP1572962.
JD535511 - Sequence 516535 from Patent EP1572962.
JD388314 - Sequence 369338 from Patent EP1572962.
JD388315 - Sequence 369339 from Patent EP1572962.
JD118429 - Sequence 99453 from Patent EP1572962.
JD517603 - Sequence 498627 from Patent EP1572962.
JD105911 - Sequence 86935 from Patent EP1572962.
JD258757 - Sequence 239781 from Patent EP1572962.
LF365611 - JP 2014500723-A/173114: Polycomb-Associated Non-Coding RNAs.
LF365612 - JP 2014500723-A/173115: Polycomb-Associated Non-Coding RNAs.
JD265642 - Sequence 246666 from Patent EP1572962.
AK056836 - Homo sapiens cDNA FLJ32274 fis, clone PROST2000036.
JD036771 - Sequence 17795 from Patent EP1572962.
JD109770 - Sequence 90794 from Patent EP1572962.
JD418918 - Sequence 399942 from Patent EP1572962.
JD259696 - Sequence 240720 from Patent EP1572962.
JD160714 - Sequence 141738 from Patent EP1572962.
JD281368 - Sequence 262392 from Patent EP1572962.
JD491940 - Sequence 472964 from Patent EP1572962.
JD546214 - Sequence 527238 from Patent EP1572962.
JD252508 - Sequence 233532 from Patent EP1572962.
JD388731 - Sequence 369755 from Patent EP1572962.
JD119170 - Sequence 100194 from Patent EP1572962.
JD212213 - Sequence 193237 from Patent EP1572962.
JD197655 - Sequence 178679 from Patent EP1572962.
JD412398 - Sequence 393422 from Patent EP1572962.
JD212034 - Sequence 193058 from Patent EP1572962.
JD107677 - Sequence 88701 from Patent EP1572962.
AK093772 - Homo sapiens cDNA FLJ36453 fis, clone THYMU2014051.
AX748298 - Sequence 1823 from Patent EP1308459.
JD295399 - Sequence 276423 from Patent EP1572962.
JD328724 - Sequence 309748 from Patent EP1572962.
JD287305 - Sequence 268329 from Patent EP1572962.
JD493432 - Sequence 474456 from Patent EP1572962.
JD342075 - Sequence 323099 from Patent EP1572962.
JD255765 - Sequence 236789 from Patent EP1572962.
JD346712 - Sequence 327736 from Patent EP1572962.
JD134113 - Sequence 115137 from Patent EP1572962.
JD121862 - Sequence 102886 from Patent EP1572962.
JD046659 - Sequence 27683 from Patent EP1572962.
JD349334 - Sequence 330358 from Patent EP1572962.
JD266577 - Sequence 247601 from Patent EP1572962.
JD344356 - Sequence 325380 from Patent EP1572962.
JD423555 - Sequence 404579 from Patent EP1572962.
JD485147 - Sequence 466171 from Patent EP1572962.
JD192240 - Sequence 173264 from Patent EP1572962.
JD373411 - Sequence 354435 from Patent EP1572962.
JD520733 - Sequence 501757 from Patent EP1572962.
JD350565 - Sequence 331589 from Patent EP1572962.
JD211641 - Sequence 192665 from Patent EP1572962.
JD518638 - Sequence 499662 from Patent EP1572962.
JD471126 - Sequence 452150 from Patent EP1572962.
JD040513 - Sequence 21537 from Patent EP1572962.
JD071051 - Sequence 52075 from Patent EP1572962.
JD323915 - Sequence 304939 from Patent EP1572962.
JD181410 - Sequence 162434 from Patent EP1572962.
JD348295 - Sequence 329319 from Patent EP1572962.
JD080786 - Sequence 61810 from Patent EP1572962.
JD439238 - Sequence 420262 from Patent EP1572962.
JD178345 - Sequence 159369 from Patent EP1572962.
JD459606 - Sequence 440630 from Patent EP1572962.
JD226652 - Sequence 207676 from Patent EP1572962.
JD360902 - Sequence 341926 from Patent EP1572962.
JD147628 - Sequence 128652 from Patent EP1572962.
JD252462 - Sequence 233486 from Patent EP1572962.
JD388103 - Sequence 369127 from Patent EP1572962.
JD288923 - Sequence 269947 from Patent EP1572962.
JD200297 - Sequence 181321 from Patent EP1572962.
JD157526 - Sequence 138550 from Patent EP1572962.
MA601183 - JP 2018138019-A/173109: Polycomb-Associated Non-Coding RNAs.
MA601186 - JP 2018138019-A/173112: Polycomb-Associated Non-Coding RNAs.
MA601187 - JP 2018138019-A/173113: Polycomb-Associated Non-Coding RNAs.
MA601188 - JP 2018138019-A/173114: Polycomb-Associated Non-Coding RNAs.
MA601189 - JP 2018138019-A/173115: Polycomb-Associated Non-Coding RNAs.
MA447647 - JP 2018138019-A/19573: Polycomb-Associated Non-Coding RNAs.
MA442942 - JP 2018138019-A/14868: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96F46 (Reactome details) participates in the following event(s):

R-HSA-448424 Interleukin-17 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000319363.1, ENST00000319363.10, ENST00000319363.2, ENST00000319363.3, ENST00000319363.4, ENST00000319363.5, ENST00000319363.6, ENST00000319363.7, ENST00000319363.8, ENST00000319363.9, I17RA_HUMAN, IL17R, IL17RA , NM_014339, O43844, Q20WK1, Q96F46, uc317qqp.1, uc317qqp.2
UCSC ID: ENST00000319363.11_9
RefSeq Accession: NM_014339.7
Protein: Q96F46 (aka I17RA_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.