ID:ITIH1_HUMAN DESCRIPTION: RecName: Full=Inter-alpha-trypsin inhibitor heavy chain H1; Short=ITI heavy chain H1; Short=ITI-HC1; Short=Inter-alpha-inhibitor heavy chain 1; AltName: Full=Inter-alpha-trypsin inhibitor complex component III; AltName: Full=Serum-derived hyaluronan-associated protein; Short=SHAP; Flags: Precursor; FUNCTION: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. FUNCTION: Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells. SUBUNIT: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin. SUBCELLULAR LOCATION: Secreted. PTM: Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage. PTM: The S-linked glycan is composed of two 6-carbon sugars, possibly Glc or Gal. MASS SPECTROMETRY: Mass=76258; Method=MALDI; Range=28-672; Source=PubMed:9677337; POLYMORPHISM: There are 3 common alleles; ITIH1*1 with Glu- 585/Gln-595, ITIH1*2 with Val-585/Arg-595 and ITIH1*3 with Glu- 585/Arg-595. SIMILARITY: Belongs to the ITIH family. SIMILARITY: Contains 1 VIT domain. SIMILARITY: Contains 1 VWFA domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00092 - von Willebrand factor type A domain PF06668 - Inter-alpha-trypsin inhibitor heavy chain C-terminus PF08487 - Vault protein inter-alpha-trypsin domain PF13519 - von Willebrand factor type A domain PF13768 - von Willebrand factor type A domain
ModBase Predicted Comparative 3D Structure on P19827
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.