Human Gene KCTD2 (ENST00000322444.7_4) from GENCODE V47lift37

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Description: potassium channel tetramerization domain containing 2, transcript variant 2 (from RefSeq NR_110834.2)
Gencode Transcript: ENST00000322444.7_4
Gencode Gene: ENSG00000180901.11_7
Transcript (Including UTRs)
Position: hg19 chr17:73,043,320-73,061,981 Size: 18,662 Total Exon Count: 6 Strand: +
Coding Region
Position: hg19 chr17:73,043,346-73,059,142 Size: 15,797 Coding Exon Count: 6

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr17:73,043,320-73,061,981)			mRNA (may differ from genome)		Protein (263 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: KCTD2_HUMAN DESCRIPTION: RecName: Full=BTB/POZ domain-containing protein KCTD2; AltName: Full=Potassium channel tetramerization domain-containing protein 2; SIMILARITY: Contains 1 BTB (POZ) domain. SEQUENCE CAUTION: Sequence=BAA11493.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine C036990 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline D000082 Acetaminophen D016604 Aflatoxin B1 D001564 Benzo(a)pyrene D004041 Dietary Fats D019833 Genistein D014810 Vitamin E C044887 beta-methylcholine C041786 palm oil more ... click here to view the complete list

Common Gene Haplotype Alleles


	Press "+" in the title bar above to open this section.

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 89.17 RPKM in Brain - Cerebellum Total median expression: 882.67 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


	Press "+" in the title bar above to open this section.

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-5.10	26	-0.196	Picture	PostScript	Text
3' UTR	-1033.40	2839	-0.364	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR003131 - T1-type_BTB

Pfam Domains:
PF02214 - BTB/POZ domain

SCOP Domains:
54695 - POZ domain

ModBase Predicted Comparative 3D Structure on Q14681


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details			Gene Details
Gene Sorter	Gene Sorter			Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0044877 macromolecular complex binding GO:0097602 cullin family protein binding Biological Process: GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0051260 protein homooligomerization Cellular Component: GO:0031463 Cul3-RING ubiquitin ligase complex

Descriptions from all associated GenBank mRNAs


	AK311278 - Homo sapiens cDNA, FLJ18320. AK307083 - Homo sapiens cDNA, FLJ97031. BC033329 - Homo sapiens potassium channel tetramerisation domain containing 2, mRNA (cDNA clone IMAGE:4830112), partial cds. D79998 - Homo sapiens KIAA0176 mRNA, complete cds. BC160142 - Synthetic construct Homo sapiens clone IMAGE:100064174, MGC:193257 potassium channel tetramerisation domain containing 2 (KCTD2) mRNA, encodes complete protein. DQ600691 - Homo sapiens piRNA piR-38757, complete sequence. AK310690 - Homo sapiens cDNA, FLJ17732. BC072404 - Homo sapiens cDNA clone IMAGE:6137062, partial cds. BC080561 - Homo sapiens potassium channel tetramerisation domain containing 2, mRNA (cDNA clone IMAGE:6339613). BC047910 - Homo sapiens potassium channel tetramerisation domain containing 2, mRNA (cDNA clone IMAGE:6021466), partial cds. BC009633 - Homo sapiens potassium channel tetramerisation domain containing 2, mRNA (cDNA clone IMAGE:3878516), partial cds. AF055014 - Homo sapiens clone 24521 mRNA sequence. DQ594673 - Homo sapiens piRNA piR-60785, complete sequence. DQ572002 - Homo sapiens piRNA piR-40114, complete sequence. DQ582248 - Homo sapiens piRNA piR-32360, complete sequence. JD531268 - Sequence 512292 from Patent EP1572962. JD367476 - Sequence 348500 from Patent EP1572962. JD404249 - Sequence 385273 from Patent EP1572962. JD235729 - Sequence 216753 from Patent EP1572962. JD207425 - Sequence 188449 from Patent EP1572962. JD116629 - Sequence 97653 from Patent EP1572962. JD179645 - Sequence 160669 from Patent EP1572962. JD442432 - Sequence 423456 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000322444.1, ENST00000322444.2, ENST00000322444.3, ENST00000322444.4, ENST00000322444.5, ENST00000322444.6, KCTD2_HUMAN, KIAA0176, NR_110834, Q14681, uc317rhc.1, uc317rhc.2 UCSC ID: ENST00000322444.7_4 RefSeq Accession: NM_015353.3 Protein: Q14681 (aka KCTD2_HUMAN or KDD2_HUMAN)

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.