Human Gene KIF19 (ENST00000389916.5_4) from GENCODE V47lift37
  Description: kinesin family member 19 (from RefSeq NM_153209.4)
Gencode Transcript: ENST00000389916.5_4
Gencode Gene: ENSG00000196169.15_7
Transcript (Including UTRs)
   Position: hg19 chr17:72,322,365-72,351,959 Size: 29,595 Total Exon Count: 20 Strand: +
Coding Region
   Position: hg19 chr17:72,322,489-72,351,451 Size: 28,963 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:72,322,365-72,351,959)mRNA (may differ from genome)Protein (998 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KIF19_HUMAN
DESCRIPTION: RecName: Full=Kinesin-like protein KIF19;
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable).
SIMILARITY: Belongs to the kinesin-like protein family.
SIMILARITY: Contains 1 kinesin-motor domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 51.24 RPKM in Nerve - Tibial
Total median expression: 124.55 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -64.30124-0.519 Picture PostScript Text
3' UTR -219.60508-0.432 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019821 - Kinesin_motor_CS
IPR001752 - Kinesin_motor_dom

Pfam Domains:
PF00225 - Kinesin motor domain
PF16796 - Microtubule binding

SCOP Domains:
158397 - TM1646-like
52540 - P-loop containing nucleoside triphosphate hydrolases
58010 - Fibrinogen coiled-coil and central regions

ModBase Predicted Comparative 3D Structure on Q2TAC6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed
GO:0016887 ATPase activity

Biological Process:
GO:0007018 microtubule-based movement
GO:0060404 axonemal microtubule depolymerization
GO:0070462 plus-end specific microtubule depolymerization

Cellular Component:
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0005929 cilium
GO:0005930 axoneme
GO:0042995 cell projection


-  Descriptions from all associated GenBank mRNAs
  BC067749 - Homo sapiens cDNA clone IMAGE:5284479.
BC026362 - Homo sapiens kinesin family member 19, mRNA (cDNA clone IMAGE:4796368).
BC110989 - Homo sapiens kinesin family member 19, mRNA (cDNA clone IMAGE:5205751), partial cds.
AK094619 - Homo sapiens cDNA FLJ37300 fis, clone BRAMY2015782, moderately similar to KINESIN-LIKE PROTEIN.
JD406567 - Sequence 387591 from Patent EP1572962.
JD407022 - Sequence 388046 from Patent EP1572962.
JD477270 - Sequence 458294 from Patent EP1572962.
BC143327 - Homo sapiens kinesin family member 19, mRNA (cDNA clone MGC:176849 IMAGE:9051832), complete cds.
BC093631 - Homo sapiens kinesin family member 19, mRNA (cDNA clone MGC:120666 IMAGE:7939476), complete cds.
BC104852 - Homo sapiens kinesin family member 19, mRNA (cDNA clone MGC:132512 IMAGE:8143855), complete cds.
JD148950 - Sequence 129974 from Patent EP1572962.
KJ903714 - Synthetic construct Homo sapiens clone ccsbBroadEn_13108 KIF19 gene, encodes complete protein.
JD185977 - Sequence 167001 from Patent EP1572962.
JD398581 - Sequence 379605 from Patent EP1572962.
JD484608 - Sequence 465632 from Patent EP1572962.
JD099529 - Sequence 80553 from Patent EP1572962.
LV526773 - JP 2016539084-A/3: METHODS AND COMPOSITIONS TO INHIBIT METASTASIS AND TO TREAT FIBROSIS AND TO ENHANCE WOUND HEALING.
LF209415 - JP 2014500723-A/16918: Polycomb-Associated Non-Coding RNAs.
LF328366 - JP 2014500723-A/135869: Polycomb-Associated Non-Coding RNAs.
MA563943 - JP 2018138019-A/135869: Polycomb-Associated Non-Coding RNAs.
MA444992 - JP 2018138019-A/16918: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q2TAC6 (Reactome details) participates in the following event(s):

R-HSA-983266 Kinesins bind microtubules
R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules
R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs
R-HSA-983189 Kinesins
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-109582 Hemostasis
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: A6NLG2, B7ZKR1, ENST00000389916.1, ENST00000389916.2, ENST00000389916.3, ENST00000389916.4, KIF19_HUMAN, NM_153209, Q2TAC6, Q52M87, Q8N1X8, Q8TAB6, uc318tje.1, uc318tje.2
UCSC ID: ENST00000389916.5_4
RefSeq Accession: NM_153209.4
Protein: Q2TAC6 (aka KIF19_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.