Human Gene KIR2DS4 (ENST00000339924.12_8) from GENCODE V47lift37
  Description: killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4 (from HGNC KIR2DS4)
Gencode Transcript: ENST00000339924.12_8
Gencode Gene: ENSG00000221957.8_12
Transcript (Including UTRs)
   Position: hg19 chr19:55,344,131-55,360,024 Size: 15,894 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr19:55,344,220-55,359,398 Size: 15,179 Coding Exon Count: 8 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:55,344,131-55,360,024)mRNA (may differ from genome)Protein (297 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
EnsemblExonPrimerGeneCardsHGNCMalacardsMGI
PubMedWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KIR2DS4
Diseases sorted by gene-association score: craniofacial-deafness-hand syndrome (6), waardenburg's syndrome (4), birdshot chorioretinopathy (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.85 RPKM in Whole Blood
Total median expression: 5.16 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -33.3089-0.374 Picture PostScript Text
3' UTR -139.23626-0.222 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
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-  Descriptions from all associated GenBank mRNAs
  AF135557 - Homo sapiens p58 killer cell inhibitory receptor KIR-K36 (KIR-K36) mRNA, partial cds.
BC108918 - Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4, mRNA (cDNA clone MGC:120019 IMAGE:40017300), complete cds.
BC125147 - Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4, mRNA (cDNA clone IMAGE:40120230), partial cds.
AJ417554 - Homo sapiens partial mRNA for killer cell immunoglobulin receptor (KIR2DS4 gene), strain 3321.
AJ417555 - Homo sapiens partial mRNA for killer cell immunoglobulin receptor (KIR2DS4 gene), strain 4053.
BC143618 - Homo sapiens cDNA clone IMAGE:9052131.
BC143616 - Homo sapiens cDNA clone IMAGE:9052129.
KJ904494 - Synthetic construct Homo sapiens clone ccsbBroadEn_13888 KIR2DS4-like gene, encodes complete protein.
BC144566 - Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4, mRNA (cDNA clone MGC:178111 IMAGE:9053094), complete cds.
BC171788 - Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4, mRNA (cDNA clone MGC:198503 IMAGE:9054442), complete cds.
X94609 - H.sapiens mRNA for activatory NK receptor/KKA3 p50.3.
AF002255 - Homo sapiens killer cell inhibitory receptor cl-17 mRNA, complete cds.
AY388472 - Homo sapiens natural killer cell Ig-like receptor KIR2DS4 (KIR2DS4) mRNA, KIR2DS4*00101 allele, complete cds.
AY366245 - Homo sapiens natural killer cell inhibitory receptor (KIR2DS4) mRNA, KIR2DS4*0010103 allele, complete cds.
BC127084 - Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4, mRNA (cDNA clone MGC:150419 IMAGE:40120468), complete cds.
BC096694 - Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4, mRNA (cDNA clone MGC:119727 IMAGE:40026979), complete cds.
BC101977 - Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4, mRNA (cDNA clone MGC:125315 IMAGE:40004312), complete cds.
BC103693 - Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4, mRNA (cDNA clone MGC:125317 IMAGE:40004314), complete cds.
L76671 - Homo sapiens nkat8 mRNA, complete cds.
AY366246 - Homo sapiens natural killer cell inhibitory receptor (KIR2DS4) mRNA, KIR2DS4*004 allele, complete cds.
KJ905223 - Synthetic construct Homo sapiens clone ccsbBroadEn_14687 KIR2DS4-like gene, encodes complete protein.
AB590477 - Synthetic construct DNA, clone: pFN21AE2115, Homo sapiens KIR2DS4 gene for killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4, without stop codon, in Flexi system.
AY102623 - Homo sapiens KIR1D splice variant mRNA, complete cds.
LS974077 - Homo sapiens mRNA for KIR2DS4 protein (KIR2DS4 gene), isolate 85, allele Ins54bp_(Cry)_hKIR2DS4_00401.
LS974082 - Homo sapiens mRNA for KIR2DS4 protein (KIR2DS4 gene), isolate 02, 04, allele Del51bp_(ex6)_hKIR2DS4_0010101.
LS974107 - Homo sapiens mRNA for KIR2DS4 protein (KIR2DS4 gene), isolate 04, 85, allele Del294bp_(3-5ss)_hKIR2DS4_00101.
U24077 - Human p58 natural killer cell receptor precursor mRNA, clone cl-39, complete cds.
AY789064 - Homo sapiens truncated natural killer cell inhibitory receptor (KIR2DS4) mRNA, KIR2DS4*007 allele, partial cds.
AJ620615 - Homo sapiens mRNA for truncated killer cell immunoglobulin-like receptor (KIR2DS4 gene), isolate B160(v2).
AJ620616 - Homo sapiens partial mRNA for truncated killer cell immunoglobulin-like receptor (KIR2DS4 gene), isolate B193(v1).
AF135563 - Homo sapiens p50 killer cell activating receptor KAR-K1a mRNA, alternatively spliced, partial cds.
AF135559 - Homo sapiens p58 killer cell inhibitory receptor KIR-K61 (KIR-K61) mRNA, partial cds.
AF135561 - Homo sapiens p58 killer cell inhibitory receptor KIR-K65 (KIR-K65) mRNA, partial cds.
AF135562 - Homo sapiens p58 killer cell inhibitory receptor KIR-K78 (KIR-K78) mRNA, partial cds.
AF135564 - Homo sapiens p50 killer cell activating receptor KAR-K1d mRNA, alternatively spliced, partial cds.
U96188 - Homo sapiens p50 cell activatory receptor NKR-K1 mRNA, partial cds.
AY102624 - Homo sapiens KIR1D mRNA, partial cds.
JD120841 - Sequence 101865 from Patent EP1572962.
JD304256 - Sequence 285280 from Patent EP1572962.
JD171693 - Sequence 152717 from Patent EP1572962.
JD353404 - Sequence 334428 from Patent EP1572962.
JD353407 - Sequence 334431 from Patent EP1572962.
JD228897 - Sequence 209921 from Patent EP1572962.
JD525272 - Sequence 506296 from Patent EP1572962.
JD291661 - Sequence 272685 from Patent EP1572962.
JD533385 - Sequence 514409 from Patent EP1572962.
JD063768 - Sequence 44792 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000339924.1, ENST00000339924.10, ENST00000339924.11, ENST00000339924.2, ENST00000339924.3, ENST00000339924.4, ENST00000339924.5, ENST00000339924.6, ENST00000339924.7, ENST00000339924.8, ENST00000339924.9, U24077, uc317vmv.1, uc317vmv.2
UCSC ID: ENST00000339924.12_8
RefSeq Accession: NM_001281971.2

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.