Human Gene KRT222 (ENST00000394049.5_4) from GENCODE V47lift37

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Description: keratin 222 (from HGNC KRT222)
Gencode Transcript: ENST00000394049.5_4
Gencode Gene: ENSG00000213424.9_10
Transcript (Including UTRs)
Position: hg19 chr17:38,810,917-38,821,408 Size: 10,492 Total Exon Count: 6 Strand: -
Coding Region
Position: hg19 chr17:38,821,175-38,821,351 Size: 177 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
Microarray Expression	RNA Structure	Protein Structure	Other Species	mRNA Descriptions	Other Names
Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr17:38,810,917-38,821,408)			mRNA (may differ from genome)		Protein (58 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	ExonPrimer	GeneCards	HGNC
MGI	PubMed	UniProtKB

Comments and Description Text from UniProtKB


	ID: J3QQR9_HUMAN DESCRIPTION: SubName: Full=Keratin-like protein KRT222; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D016604 Aflatoxin B1 D016572 Cyclosporine D004958 Estradiol D007545 Isoproterenol D013739 Testosterone C006253 pirinixic acid

Common Gene Haplotype Alleles


	Press "+" in the title bar above to open this section.

Microarray Expression Data


	Press "+" in the title bar above to open this section.

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-14.60	57	-0.256	Picture	PostScript	Text
3' UTR	-563.90	2530	-0.223	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

ModBase Predicted Comparative 3D Structure on J3QQR9


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Descriptions from all associated GenBank mRNAs


	AK092967 - Homo sapiens cDNA FLJ35648 fis, clone SPLEN2013195, highly similar to Homo sapiens BAF57 (BAF57) gene. BX538083 - Homo sapiens mRNA; cDNA DKFZp686P24273 (from clone DKFZp686P24273); complete cds. BC032815 - Homo sapiens keratin 222 pseudogene, mRNA (cDNA clone MGC:45562 IMAGE:4346009), complete cds. JD184041 - Sequence 165065 from Patent EP1572962. JD326997 - Sequence 308021 from Patent EP1572962. EU831766 - Synthetic construct Homo sapiens clone HAIB:100066795; DKFZo008B1021 keratin 222 pseudogene protein (KRT222P) gene, encodes complete protein. EU832123 - Synthetic construct Homo sapiens clone HAIB:100067152; DKFZo008D0125 keratin 222 pseudogene protein (KRT222P) gene, encodes complete protein. KJ895403 - Synthetic construct Homo sapiens clone ccsbBroadEn_04797 KRT222 gene, encodes complete protein. EU831844 - Synthetic construct Homo sapiens clone HAIB:100066873; DKFZo004B1022 keratin 222 pseudogene protein (KRT222P) gene, encodes complete protein. EU832217 - Synthetic construct Homo sapiens clone HAIB:100067246; DKFZo004D0126 keratin 222 pseudogene protein (KRT222P) gene, encodes complete protein. AK308598 - Homo sapiens cDNA, FLJ98639.

Other Names for This Gene


	Alternate Gene Symbols: BX538083, ENST00000394049.1, ENST00000394049.2, ENST00000394049.3, ENST00000394049.4, J3QQR9, J3QQR9_HUMAN, KRT222 , uc318wif.1 UCSC ID: ENST00000394049.5_4 RefSeq Accession: NM_152349.3 Protein: J3QQR9

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.