Human Gene KRTAP2-4 (ENST00000394015.3_6) from GENCODE V47lift37

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Description: keratin associated protein 2-4 (from RefSeq NM_033184.4)
Gencode Transcript: ENST00000394015.3_6
Gencode Gene: ENSG00000213417.3_7
Transcript (Including UTRs)
Position: hg19 chr17:39,221,368-39,222,131 Size: 764 Total Exon Count: 1 Strand: -
Coding Region
Position: hg19 chr17:39,221,711-39,222,097 Size: 387 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr17:39,221,368-39,222,131)			mRNA (may differ from genome)		Protein (128 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	PubMed	Reactome	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: KRA24_HUMAN DESCRIPTION: RecName: Full=Keratin-associated protein 2-4; AltName: Full=High sulfur keratin-associated protein 2.4; AltName: Full=Keratin-associated protein 2.4; FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (By similarity). SUBUNIT: Interacts with hair keratins (By similarity). TISSUE SPECIFICITY: Expressed specifically in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone. SIMILARITY: Belongs to the KRTAP type 2 family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D019327 Copper Sulfate D005557 Formaldehyde D019833 Genistein C016517 indole-3-carbinol

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 0.00 RPKM in (null) Total median expression: 0.00 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	0.00	34	0.000	Picture	PostScript	Text
3' UTR	-75.20	343	-0.219	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR002494 - Keratin-assoc

Pfam Domains:
PF01500 - Keratin, high sulfur B2 protein
PF13885 - Keratin, high sulfur B2 protein

ModBase Predicted Comparative 3D Structure on Q9BYR9


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding Biological Process: GO:0031424 keratinization Cellular Component: GO:0005829 cytosol GO:0005882 intermediate filament GO:0045095 keratin filament

Descriptions from all associated GenBank mRNAs


	AJ406929 - Homo sapiens partial mRNA for keratin associated protein 2.1b (KRTAP2.1B gene). AJ406930 - Homo sapiens mRNA for keratin associated protein 2.4 (KRTAP2.4 gene). BC101147 - Homo sapiens keratin associated protein 2-4, mRNA (cDNA clone MGC:119882 IMAGE:40015180), complete cds. BC101148 - Homo sapiens keratin associated protein 2-4, mRNA (cDNA clone MGC:119884 IMAGE:40015187), complete cds. BC101149 - Homo sapiens keratin associated protein 2-4, mRNA (cDNA clone MGC:119885 IMAGE:40015188), complete cds. JD281370 - Sequence 262394 from Patent EP1572962. JD166294 - Sequence 147318 from Patent EP1572962. JD490738 - Sequence 471762 from Patent EP1572962. JD258254 - Sequence 239278 from Patent EP1572962. JD491018 - Sequence 472042 from Patent EP1572962. JD184587 - Sequence 165611 from Patent EP1572962. JD121357 - Sequence 102381 from Patent EP1572962. JD470502 - Sequence 451526 from Patent EP1572962. JD272485 - Sequence 253509 from Patent EP1572962. JD423935 - Sequence 404959 from Patent EP1572962. JD400147 - Sequence 381171 from Patent EP1572962. JD437668 - Sequence 418692 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9BYR9 (Reactome details) participates in the following event(s): R-HSA-6805567 Keratinization R-HSA-1266738 Developmental Biology

Other Names for This Gene


	Alternate Gene Symbols: ENST00000394015.1, ENST00000394015.2, KAP2.4, KRA24_HUMAN, KRTAP2.4, NM_033184, Q495J2, Q9BYR9, uc318wht.1, uc318wht.2 UCSC ID: ENST00000394015.3_6 RefSeq Accession: NM_033184.4 Protein: Q9BYR9 (aka KRA24_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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