Human Gene KSR1 (ENST00000644974.2_5) from GENCODE V47lift37

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Description: kinase suppressor of ras 1, transcript variant 3 (from RefSeq NM_001394583.1)
Gencode Transcript: ENST00000644974.2_5
Gencode Gene: ENSG00000141068.17_16
Transcript (Including UTRs)
Position: hg19 chr17:25,783,474-25,953,461 Size: 169,988 Total Exon Count: 21 Strand: +
Coding Region
Position: hg19 chr17:25,783,670-25,950,418 Size: 166,749 Coding Exon Count: 21

Page Index	Sequence and Links	Primers	CTD	Gene Alleles	Microarray Expression
RNA Structure	Other Species	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr17:25,783,474-25,953,461)			mRNA (may differ from genome)		Protein (928 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	ExonPrimer	GeneCards	HGNC
MGI	PubMed	UniProtKB	Wikipedia

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C012606 4-vinyl-1-cyclohexene dioxide D001554 Benzene D002117 Calcitriol D003993 Dibutyl Phthalate D008731 Methoxychlor D012999 Soman D013749 Tetrachlorodibenzodioxin D014118 Toxins, Biological D015032 Zinc C496492 abrine more ... click here to view the complete list

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-111.60	196	-0.569	Picture	PostScript	Text
3' UTR	-1115.30	3043	-0.367	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Descriptions from all associated GenBank mRNAs


	U43586 - Human kinase suppressor of ras-1 (KSR1) mRNA, partial cds. BC035488 - Homo sapiens kinase suppressor of ras 1, mRNA (cDNA clone IMAGE:5166671). BC042106 - Homo sapiens kinase suppressor of ras 1, mRNA (cDNA clone IMAGE:5168484), partial cds. AK124344 - Homo sapiens cDNA FLJ42353 fis, clone UTERU2007520. AK095721 - Homo sapiens cDNA FLJ38402 fis, clone FEBRA2008210. AK130719 - Homo sapiens cDNA FLJ27209 fis, clone SYN03476. JD400182 - Sequence 381206 from Patent EP1572962. BC167812 - Synthetic construct Homo sapiens clone IMAGE:100068202, MGC:195819 kinase suppressor of ras 1 (KSR1) mRNA, encodes complete protein. JD495312 - Sequence 476336 from Patent EP1572962. JD320899 - Sequence 301923 from Patent EP1572962. JD125172 - Sequence 106196 from Patent EP1572962. DQ578239 - Homo sapiens piRNA piR-46351, complete sequence. BC037586 - Homo sapiens kinase suppressor of ras 1, mRNA (cDNA clone IMAGE:5194476), with apparent retained intron. DQ587176 - Homo sapiens piRNA piR-54288, complete sequence. JD364082 - Sequence 345106 from Patent EP1572962. JD207370 - Sequence 188394 from Patent EP1572962. JD368498 - Sequence 349522 from Patent EP1572962. JD295813 - Sequence 276837 from Patent EP1572962. JD489616 - Sequence 470640 from Patent EP1572962. JD535144 - Sequence 516168 from Patent EP1572962. JD402631 - Sequence 383655 from Patent EP1572962. JD164490 - Sequence 145514 from Patent EP1572962. JD251799 - Sequence 232823 from Patent EP1572962. JD557646 - Sequence 538670 from Patent EP1572962. JD463373 - Sequence 444397 from Patent EP1572962. JD233199 - Sequence 214223 from Patent EP1572962. JD115931 - Sequence 96955 from Patent EP1572962. JD365796 - Sequence 346820 from Patent EP1572962. JD347847 - Sequence 328871 from Patent EP1572962. JD065032 - Sequence 46056 from Patent EP1572962. JD072681 - Sequence 53705 from Patent EP1572962. JD545713 - Sequence 526737 from Patent EP1572962. JD285624 - Sequence 266648 from Patent EP1572962. JD163558 - Sequence 144582 from Patent EP1572962. JD560597 - Sequence 541621 from Patent EP1572962. JD298675 - Sequence 279699 from Patent EP1572962. JD522137 - Sequence 503161 from Patent EP1572962. JD109359 - Sequence 90383 from Patent EP1572962. JD149930 - Sequence 130954 from Patent EP1572962. JD486966 - Sequence 467990 from Patent EP1572962. JD243036 - Sequence 224060 from Patent EP1572962. JD237057 - Sequence 218081 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A0A2R8Y5H9, A0A2R8Y5H9_HUMAN, ENST00000644974.1, KSR1 , NM_001394583, uc328ldh.1, uc328ldh.2 UCSC ID: ENST00000644974.2_5 RefSeq Accession: NM_001394583.1

Gene Model Information


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Methods, Credits, and Use Restrictions


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