ID:LMX1A_HUMAN DESCRIPTION: RecName: Full=LIM homeobox transcription factor 1-alpha; AltName: Full=LIM/homeobox protein 1.1; Short=LMX-1.1; AltName: Full=LIM/homeobox protein LMX1A; FUNCTION: Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Isoform 1 is expressed in many tissues. Not found in heart, liver, spleen and testis. Relatively highly expressed in fetal brain. Isoform LMX1A-4B is expressed in testis. SIMILARITY: Contains 1 homeobox DNA-binding domain. SIMILARITY: Contains 2 LIM zinc-binding domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TE12
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0001558 regulation of cell growth GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0007411 axon guidance GO:0007417 central nervous system development GO:0007420 brain development GO:0007613 memory GO:0007626 locomotory behavior GO:0010468 regulation of gene expression GO:0021542 dentate gyrus development GO:0021549 cerebellum development GO:0021766 hippocampus development GO:0021953 central nervous system neuron differentiation GO:0030182 neuron differentiation GO:0030901 midbrain development GO:0042048 olfactory behavior GO:0045665 negative regulation of neuron differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050808 synapse organization GO:0071542 dopaminergic neuron differentiation GO:1904948 midbrain dopaminergic neuron differentiation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
