Human Gene ADGRL2 (ENST00000319517.10_3) from GENCODE V47lift37
  Description: adhesion G protein-coupled receptor L2, transcript variant 1 (from RefSeq NM_012302.5)
Gencode Transcript: ENST00000319517.10_3
Gencode Gene: ENSG00000117114.21_17
Transcript (Including UTRs)
   Position: hg19 chr1:82,266,082-82,457,880 Size: 191,799 Total Exon Count: 20 Strand: +
Coding Region
   Position: hg19 chr1:82,302,670-82,456,829 Size: 154,160 Coding Exon Count: 19 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:82,266,082-82,457,880)mRNA (may differ from genome)Protein (1403 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMalacards
MGIOMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LPHN2_HUMAN
DESCRIPTION: RecName: Full=Latrophilin-2; AltName: Full=Calcium-independent alpha-latrotoxin receptor 2; Short=CIRL-2; AltName: Full=Latrophilin homolog 1; AltName: Full=Lectomedin-1; Flags: Precursor;
FUNCTION: Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis (By similarity).
SUBUNIT: Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85) (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others.
PTM: Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit (By similarity).
SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
SIMILARITY: Contains 1 GPS domain.
SIMILARITY: Contains 1 olfactomedin-like domain.
SIMILARITY: Contains 1 SUEL-type lectin domain.
SEQUENCE CAUTION: Sequence=CAI22406.1; Type=Erroneous gene model prediction;
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/LPHH1ID313.html";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ADGRL2
Diseases sorted by gene-association score: dermatophytosis (6)

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.77 RPKM in Lung
Total median expression: 342.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -55.60216-0.257 Picture PostScript Text
3' UTR -233.501051-0.222 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022624 - DUF3497
IPR017981 - GPCR_2-like
IPR001879 - GPCR_2_extracellular_dom
IPR003924 - GPCR_2_latrophilin
IPR003334 - GPCR_2_latrophilin_rcpt_C
IPR000832 - GPCR_2_secretin-like
IPR017983 - GPCR_2_secretin-like_CS
IPR000203 - GPS_dom
IPR000922 - Lectin_gal-bd_dom
IPR003112 - Olfac-like

Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF01825 - GPCR proteolysis site, GPS, motif
PF02140 - Galactose binding lectin domain
PF02191 - Olfactomedin-like domain
PF02354 - Latrophilin Cytoplasmic C-terminal region
PF02793 - Hormone receptor domain
PF16489 - GPCR-Autoproteolysis INducing (GAIN) domain

SCOP Domains:
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
101898 - NHL repeat
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
82171 - DPP6 N-terminal domain-like
81321 - Family A G protein-coupled receptor-like
111418 - Hormone receptor domain

ModBase Predicted Comparative 3D Structure on O95490
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0016524 latrotoxin receptor activity
GO:0030246 carbohydrate binding

Biological Process:
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK123422 - Homo sapiens cDNA FLJ41428 fis, clone BRHIP2005236, highly similar to Latrophilin-2 precursor.
AJ131581 - Homo sapiens mRNA for latrophilin-2.
AF104266 - Homo sapiens lectomedin-1 alpha (LEC1) mRNA, complete cds.
AF104938 - Homo sapiens lectomedin-1 beta (LEC1) mRNA, complete cds.
AF104939 - Homo sapiens lectomedin-1 gamma (LEC1) mRNA, complete cds.
BC172872 - Synthetic construct Homo sapiens clone IMAGE:9094448 latrophilin 2 precursor (LPHN2) gene, partial cds.
AB018329 - Homo sapiens mRNA for KIAA0786 protein, partial cds.
BC172873 - Synthetic construct Homo sapiens clone IMAGE:9094449 latrophilin 2 precursor (LPHN2) gene, partial cds.
DQ925675 - Homo sapiens clone 2-2 latrophilin 2 precursor (LPHN2) mRNA, partial cds, alternatively spliced.
JD404369 - Sequence 385393 from Patent EP1572962.
JD316807 - Sequence 297831 from Patent EP1572962.
JD149896 - Sequence 130920 from Patent EP1572962.
JD044493 - Sequence 25517 from Patent EP1572962.
JD484801 - Sequence 465825 from Patent EP1572962.
JD261286 - Sequence 242310 from Patent EP1572962.
JD240695 - Sequence 221719 from Patent EP1572962.
JD183742 - Sequence 164766 from Patent EP1572962.
JD067370 - Sequence 48394 from Patent EP1572962.
JD521204 - Sequence 502228 from Patent EP1572962.
JD391194 - Sequence 372218 from Patent EP1572962.
JD474167 - Sequence 455191 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A5XEI2, ADGRL2 , AGRL2_HUMAN, B1ALT8, B1ALT9, B1ALU0, B1ALU2, B1ALU4, B1ALU5, B1ALU6, ENST00000319517.1, ENST00000319517.2, ENST00000319517.3, ENST00000319517.4, ENST00000319517.5, ENST00000319517.6, ENST00000319517.7, ENST00000319517.8, ENST00000319517.9, KIAA0786, LEC1, LPHH1, LPHN2, NM_012302, O94882, O95490, Q5VX76, Q9UKY5, Q9UKY6, uc317qrn.1
UCSC ID: ENST00000319517.10_3
RefSeq Accession: NM_012302.5
Protein: O95490 (aka LPHN2_HUMAN or LHN2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.