ID:LPHN2_HUMAN DESCRIPTION: RecName: Full=Latrophilin-2; AltName: Full=Calcium-independent alpha-latrotoxin receptor 2; Short=CIRL-2; AltName: Full=Latrophilin homolog 1; AltName: Full=Lectomedin-1; Flags: Precursor; FUNCTION: Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis (By similarity). SUBUNIT: Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85) (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others. PTM: Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit (By similarity). SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. SIMILARITY: Contains 1 GPS domain. SIMILARITY: Contains 1 olfactomedin-like domain. SIMILARITY: Contains 1 SUEL-type lectin domain. SEQUENCE CAUTION: Sequence=CAI22406.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/LPHH1ID313.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 63825 - YWTD domain 63829 - Calcium-dependent phosphotriesterase 101898 - NHL repeat 50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase 82171 - DPP6 N-terminal domain-like 81321 - Family A G protein-coupled receptor-like 111418 - Hormone receptor domain
ModBase Predicted Comparative 3D Structure on O95490
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.