ID:LLR1_HUMAN DESCRIPTION: RecName: Full=Leucine-rich repeat protein 1; AltName: Full=4-1BB-mediated-signaling molecule; AltName: Full=4-1BBlrr; AltName: Full=LRR-repeat protein 1; Short=LRR-1; AltName: Full=Peptidylprolyl isomerase-like 5; FUNCTION: May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with the cytoplasmic domain of TNFRSF9. Component of the probable ECS(LRR1) E3 ubiquitin-protein ligase complex which contains CUL2, RBX1, Elongin BC complex and LRR1. Interacts with CUL2, RBX1, TCEB1 and TCEB2. TISSUE SPECIFICITY: Ubiquitous. Maximal expression was seen in the heart and skeletal muscle and minimal expression seen in the kidney. SIMILARITY: Contains 7 LRR (leucine-rich) repeats. SEQUENCE CAUTION: Sequence=CAD62625.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 52047 - RNI-like 52058 - L domain-like 52075 - Outer arm dynein light chain 1
ModBase Predicted Comparative 3D Structure on Q96L50
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0005225 volume-sensitive anion channel activity
Biological Process: GO:0007165 signal transduction GO:0016567 protein ubiquitination GO:0043687 post-translational protein modification GO:0098656 anion transmembrane transport
BC030142 - Homo sapiens peptidylprolyl isomerase (cyclophilin)-like 5, mRNA (cDNA clone IMAGE:4764756), complete cds. BX648029 - Homo sapiens mRNA; cDNA DKFZp686J1525 (from clone DKFZp686J1525). BC064133 - Homo sapiens peptidylprolyl isomerase (cyclophilin)-like 5, mRNA (cDNA clone IMAGE:6501107), complete cds. BC107888 - Homo sapiens peptidylprolyl isomerase (cyclophilin)-like 5, mRNA (cDNA clone IMAGE:6653458), complete cds. BX248298 - human full-length cDNA clone CS0DK007YE23 of HeLa cells of Homo sapiens (human). BC139921 - Homo sapiens peptidylprolyl isomerase (cyclophilin)-like 5, mRNA (cDNA clone MGC:164995 IMAGE:40148567), complete cds. AK293156 - Homo sapiens cDNA FLJ54648 complete cds, highly similar to Peptidylprolyl isomerase-like 5. BC093697 - Homo sapiens peptidylprolyl isomerase (cyclophilin)-like 5, mRNA (cDNA clone IMAGE:7939542), complete cds. BC112241 - Homo sapiens peptidylprolyl isomerase (cyclophilin)-like 5, mRNA (cDNA clone IMAGE:8327709), complete cds. GQ891418 - Homo sapiens clone HEL-S-139 epididymis secretory sperm binding protein mRNA, complete cds. AY052405 - Homo sapiens 4-1BB-mediated signaling molecule mRNA, complete cds. DQ895470 - Synthetic construct Homo sapiens clone IMAGE:100009930; FLH184731.01L; RZPDo839B04145D peptidylprolyl isomerase (cyclophilin)-like 5 (PPIL5) gene, encodes complete protein. DQ892269 - Synthetic construct clone IMAGE:100004899; FLH184735.01X; RZPDo839B04146D peptidylprolyl isomerase (cyclophilin)-like 5 (PPIL5) gene, encodes complete protein. KJ906412 - Synthetic construct Homo sapiens clone ccsbBroadEn_16082 LRR1 gene, encodes complete protein. AB464006 - Synthetic construct DNA, clone: pF1KB7393, Homo sapiens PPIL5 gene for peptidylprolyl isomerase (cyclophilin)-like 5, without stop codon, in Flexi system. BC146425 - Synthetic construct Homo sapiens clone IMAGE:100015127, MGC:180214 peptidylprolyl isomerase (cyclophilin)-like 5 (PPIL5) mRNA, encodes complete protein. BC148859 - Synthetic construct Homo sapiens clone IMAGE:100015875, MGC:183201 peptidylprolyl isomerase (cyclophilin)-like 5 (PPIL5) mRNA, encodes complete protein. JD290261 - Sequence 271285 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q96L50 (Reactome details) participates in the following event(s):
R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983147 Release of E3 from polyubiquitinated substrate R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases R-HSA-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes R-HSA-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-8951664 Neddylation R-HSA-1280218 Adaptive Immune System R-HSA-597592 Post-translational protein modification R-HSA-168256 Immune System R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
