ID:MAP1A_HUMAN DESCRIPTION: RecName: Full=Microtubule-associated protein 1A; Short=MAP-1A; AltName: Full=Proliferation-related protein p80; Contains: RecName: Full=MAP1A heavy chain; Contains: RecName: Full=MAP1 light chain LC2; FUNCTION: Structural protein involved in the filamentous cross- bridging between microtubules and other skeletal elements. SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with TIAM2. Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG4. Binds to CSNK1D (By similarity). INTERACTION: Q9NRI5:DISC1; NbExp=3; IntAct=EBI-929047, EBI-529989; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable). TISSUE SPECIFICITY: Brain. DOMAIN: The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules. PTM: Phosphorylated by CSNK1D (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. PTM: LC2 is generated from MAP1A by proteolytic processing. SIMILARITY: Belongs to the MAP1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P78559
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000226 microtubule cytoskeleton organization GO:0007613 memory GO:0008306 associative learning GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0048167 regulation of synaptic plasticity GO:0099641 anterograde axonal protein transport GO:0099642 retrograde axonal protein transport GO:1903829 positive regulation of cellular protein localization GO:2000010 positive regulation of protein localization to cell surface
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
