Human Gene MAP9 (ENST00000311277.9_9) from GENCODE V47lift37
  Description: microtubule associated protein 9 (from RefSeq NM_001039580.2)
Gencode Transcript: ENST00000311277.9_9
Gencode Gene: ENSG00000164114.19_13
Transcript (Including UTRs)
   Position: hg19 chr4:156,263,810-156,298,117 Size: 34,308 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg19 chr4:156,268,935-156,297,002 Size: 28,068 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:156,263,810-156,298,117)mRNA (may differ from genome)Protein (647 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MAP9_HUMAN
DESCRIPTION: RecName: Full=Microtubule-associated protein 9; AltName: Full=Aster-associated protein;
FUNCTION: Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules.
SUBUNIT: Binds to purified microtubules via its C-terminus.
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Localizes to microtubules in interphase, associates with the mitotic spindle during mitosis, localizes to the central body during cytokinesis.
DEVELOPMENTAL STAGE: Constitutively expressed during the cell cycle.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.39 RPKM in Pituitary
Total median expression: 103.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -86.70259-0.335 Picture PostScript Text
3' UTR -1130.905125-0.221 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026106 - MAP9

ModBase Predicted Comparative 3D Structure on Q49MG5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008017 microtubule binding

Biological Process:
GO:0000910 cytokinesis
GO:0007049 cell cycle
GO:0007088 regulation of mitotic nuclear division
GO:0046602 regulation of mitotic centrosome separation
GO:0051225 spindle assembly
GO:0051301 cell division
GO:0060236 regulation of mitotic spindle organization
GO:0090307 mitotic spindle assembly
GO:1902412 regulation of mitotic cytokinesis

Cellular Component:
GO:0000235 astral microtubule
GO:0005737 cytoplasm
GO:0005818 aster
GO:0005819 spindle
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton
GO:0030424 axon
GO:0051233 spindle midzone
GO:0072686 mitotic spindle
GO:1990023 mitotic spindle midzone


-  Descriptions from all associated GenBank mRNAs
  CR749274 - Homo sapiens mRNA; cDNA DKFZp781M044 (from clone DKFZp781M044).
BC146864 - Homo sapiens microtubule-associated protein 9, mRNA (cDNA clone MGC:181967 IMAGE:9056792), complete cds.
AY690636 - Homo sapiens ASAP mRNA, complete cds.
AK301075 - Homo sapiens cDNA FLJ57007 complete cds, highly similar to Microtubule-associated protein 9.
AK024730 - Homo sapiens cDNA: FLJ21077 fis, clone CAS02152.
AK024812 - Homo sapiens cDNA: FLJ21159 fis, clone CAS09969.
JD039840 - Sequence 20864 from Patent EP1572962.
JD313594 - Sequence 294618 from Patent EP1572962.
JD539023 - Sequence 520047 from Patent EP1572962.
JD433720 - Sequence 414744 from Patent EP1572962.
JD042305 - Sequence 23329 from Patent EP1572962.
BC128540 - Homo sapiens microtubule-associated protein 9, mRNA (cDNA clone IMAGE:40121128), partial cds.
BC128541 - Homo sapiens microtubule-associated protein 9, mRNA (cDNA clone IMAGE:40121131), partial cds.
JD263492 - Sequence 244516 from Patent EP1572962.
JD551827 - Sequence 532851 from Patent EP1572962.
BC022852 - Homo sapiens microtubule-associated protein 9, mRNA (cDNA clone IMAGE:4079119), partial cds.
BC056683 - Homo sapiens microtubule-associated protein 9, mRNA (cDNA clone IMAGE:6654819), partial cds.
JD407794 - Sequence 388818 from Patent EP1572962.
JD544717 - Sequence 525741 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ASAP, ENST00000311277.1, ENST00000311277.2, ENST00000311277.3, ENST00000311277.4, ENST00000311277.5, ENST00000311277.6, ENST00000311277.7, ENST00000311277.8, MAP9_HUMAN, NM_001039580, Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6, uc317oyr.1, uc317oyr.2
UCSC ID: ENST00000311277.9_9
RefSeq Accession: NM_001039580.2
Protein: Q49MG5 (aka MAP9_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.