Human Gene MEX3D (ENST00000402693.5_7) from GENCODE V47lift37
  Description: mex-3 RNA binding family member D, transcript variant 1 (from RefSeq NM_203304.4)
Gencode Transcript: ENST00000402693.5_7
Gencode Gene: ENSG00000181588.17_12
Transcript (Including UTRs)
   Position: hg19 chr19:1,554,671-1,568,324 Size: 13,654 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr19:1,555,562-1,568,057 Size: 12,496 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:1,554,671-1,568,324)mRNA (may differ from genome)Protein (651 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MEX3D_HUMAN
DESCRIPTION: RecName: Full=RNA-binding protein MEX3D; AltName: Full=RING finger and KH domain-containing protein 1; AltName: Full=RING finger protein 193; AltName: Full=TINO;
FUNCTION: RNA binding protein, may be involved in post- transcriptional regulatory mechanisms (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway (By similarity).
TISSUE SPECIFICITY: Ubiquitously expressed in all the cell lines and tissues tested.
DOMAIN: Binds RNA through its KH domains (By similarity).
PTM: Phosphorylated (By similarity).
SIMILARITY: Contains 2 KH domains.
SIMILARITY: Contains 1 RING-type zinc finger.
SEQUENCE CAUTION: Sequence=AAQ04763.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 77.18 RPKM in Testis
Total median expression: 315.65 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -170.80267-0.640 Picture PostScript Text
3' UTR -281.30891-0.316 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004087 - KH_dom
IPR004088 - KH_dom_type_1
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD

Pfam Domains:
PF00013 - KH domain
PF13920 - Zinc finger, C3HC4 type (RING finger)

SCOP Domains:
54791 - Eukaryotic type KH-domain (KH-domain type I)
54814 - Prokaryotic type KH domain (KH-domain type II)
57850 - RING/U-box

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2DGR - NMR


ModBase Predicted Comparative 3D Structure on Q86XN8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0017091 AU-rich element binding
GO:0046872 metal ion binding

Biological Process:
GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression
GO:0061157 mRNA destabilization

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  LF208818 - JP 2014500723-A/16321: Polycomb-Associated Non-Coding RNAs.
AB062435 - Homo sapiens mRNA for OK/SW-CL.4, complete cds.
AF458084 - Homo sapiens bcl-2 ARE RNA binding protein mRNA, partial cds.
AB107353 - Homo sapiens mRNA for KIAA2031 protein.
BC113384 - Homo sapiens mex-3 homolog D (C. elegans), mRNA (cDNA clone IMAGE:8322436), partial cds.
BC113741 - Homo sapiens mex-3 homolog D (C. elegans), mRNA (cDNA clone IMAGE:8322793), partial cds.
LF323115 - JP 2014500723-A/130618: Polycomb-Associated Non-Coding RNAs.
LF323116 - JP 2014500723-A/130619: Polycomb-Associated Non-Coding RNAs.
AY950680 - Homo sapiens MEX3D mRNA, complete cds.
LF323117 - JP 2014500723-A/130620: Polycomb-Associated Non-Coding RNAs.
LF323119 - JP 2014500723-A/130622: Polycomb-Associated Non-Coding RNAs.
DQ225272 - Homo sapiens ring finger and KH domain containing 1 protein variant 1 (RKHD1) mRNA, partial cds.
DQ225273 - Homo sapiens ring finger and KH domain containing 1 protein variant 2 (RKHD1) mRNA, partial cds.
JD056238 - Sequence 37262 from Patent EP1572962.
JD458606 - Sequence 439630 from Patent EP1572962.
JD056231 - Sequence 37255 from Patent EP1572962.
MA558692 - JP 2018138019-A/130618: Polycomb-Associated Non-Coding RNAs.
MA558693 - JP 2018138019-A/130619: Polycomb-Associated Non-Coding RNAs.
MA558694 - JP 2018138019-A/130620: Polycomb-Associated Non-Coding RNAs.
MA558696 - JP 2018138019-A/130622: Polycomb-Associated Non-Coding RNAs.
MA444395 - JP 2018138019-A/16321: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A0PJL8, A1L023, E9PAL6, ENST00000402693.1, ENST00000402693.2, ENST00000402693.3, ENST00000402693.4, KIAA2031, MEX3D_HUMAN, NM_203304, Q71M49, Q86XN8, RKHD1, RNF193, uc319bxu.1, uc319bxu.2
UCSC ID: ENST00000402693.5_7
RefSeq Accession: NM_203304.4
Protein: Q86XN8 (aka MEX3D_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.