ID:MIS12_HUMAN DESCRIPTION: RecName: Full=Protein MIS12 homolog; FUNCTION: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. SUBUNIT: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with CASC5, CBX3, CBX5, NDC80 and ZWINT. SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore. SIMILARITY: Belongs to the mis12 family. SEQUENCE CAUTION: Sequence=AK056072; Type=Frameshift; Positions=147;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H081
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK056072 - Homo sapiens cDNA FLJ31510 fis, clone NT2RI1000027. BC000229 - Homo sapiens MIS12, MIND kinetochore complex component, homolog (yeast), mRNA (cDNA clone MGC:2488 IMAGE:3351245), complete cds. AK289939 - Homo sapiens cDNA FLJ76754 complete cds, highly similar to Homo sapiens MIS12 homolog (yeast) (MIS12), mRNA. AL136906 - Homo sapiens mRNA; cDNA DKFZp434I209 (from clone DKFZp434I209). JD062921 - Sequence 43945 from Patent EP1572962. JD348969 - Sequence 329993 from Patent EP1572962. JD043473 - Sequence 24497 from Patent EP1572962. JD265691 - Sequence 246715 from Patent EP1572962. JD379567 - Sequence 360591 from Patent EP1572962. AB528182 - Synthetic construct DNA, clone: pF1KE0401, Homo sapiens MIS12 gene for Protein MIS12 homolog, without stop codon, in Flexi system. AM392972 - Synthetic construct Homo sapiens clone IMAGE:100001640 for hypothetical protein (MIS12 gene). AM393558 - Synthetic construct Homo sapiens clone IMAGE:100001646 for hypothetical protein (MIS12 gene). KJ894625 - Synthetic construct Homo sapiens clone ccsbBroadEn_04019 MIS12 gene, encodes complete protein. CR533460 - Homo sapiens full open reading frame cDNA clone RZPDo834A0317D for gene MIS12, homolog of yeast Mis12; complete cds, incl. stopcodon. JD302446 - Sequence 283470 from Patent EP1572962. JD439094 - Sequence 420118 from Patent EP1572962. JD284083 - Sequence 265107 from Patent EP1572962. JD403889 - Sequence 384913 from Patent EP1572962. JD298667 - Sequence 279691 from Patent EP1572962. JD291160 - Sequence 272184 from Patent EP1572962. JD262106 - Sequence 243130 from Patent EP1572962. JD165261 - Sequence 146285 from Patent EP1572962. JD542949 - Sequence 523973 from Patent EP1572962. JD213163 - Sequence 194187 from Patent EP1572962. JD463144 - Sequence 444168 from Patent EP1572962. JD533895 - Sequence 514919 from Patent EP1572962. JD069862 - Sequence 50886 from Patent EP1572962. JD337285 - Sequence 318309 from Patent EP1572962. JD470310 - Sequence 451334 from Patent EP1572962. JD098672 - Sequence 79696 from Patent EP1572962. JD244350 - Sequence 225374 from Patent EP1572962. JD066387 - Sequence 47411 from Patent EP1572962. JD300471 - Sequence 281495 from Patent EP1572962. JD094306 - Sequence 75330 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9H081 (Reactome details) participates in the following event(s):
R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
