Human Gene MOB4 (ENST00000323303.9_4) from GENCODE V47lift37

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Description: MOB family member 4, phocein, transcript variant 1 (from RefSeq NM_015387.5)
Gencode Transcript: ENST00000323303.9_4
Gencode Gene: ENSG00000115540.15_8
Transcript (Including UTRs)
Position: hg19 chr2:198,380,790-198,418,423 Size: 37,634 Total Exon Count: 8 Strand: +
Coding Region
Position: hg19 chr2:198,380,811-198,415,370 Size: 34,560 Coding Exon Count: 8

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:198,380,790-198,418,423)			mRNA (may differ from genome)		Protein (225 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: PHOCN_HUMAN DESCRIPTION: RecName: Full=MOB-like protein phocein; AltName: Full=2C4D; AltName: Full=Class II mMOB1; AltName: Full=Mob1 homolog 3; Short=Mob3; AltName: Full=Mps one binder kinase activator-like 3; AltName: Full=Preimplantation protein 3; FUNCTION: May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity). SUBUNIT: Binds STRN4 (By similarity). Interacts with DNM1 and EPS15 (By similarity). Interacts with nucleoside diphosphate kinase (By similarity). Binds STRN and STRN3. Part of a ternary complex containing MOB4/PHOCN, STRN and/or STRN3 and PPA2. INTERACTION: Q9P2B4:CTTNBP2NL; NbExp=5; IntAct=EBI-713935, EBI-1774273; O43815:STRN; NbExp=3; IntAct=EBI-713935, EBI-1046642; Q9Y228:TRAF3IP3; NbExp=2; IntAct=EBI-713935, EBI-765817; SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Note=In a perinuclear punctate pattern. Associated with membranes and the Golgi stacks. PTM: Phosphorylated on serine residues. SIMILARITY: Belongs to the MOB1/phocein family. SEQUENCE CAUTION: Sequence=AAP97221.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB45697.1; Type=Frameshift; Positions=168;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: MOB4 Diseases sorted by gene-association score: myeloproliferative syndrome, transient (6), cerebral cavernous malformations 3 (5), central nervous system hemangioma (5)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D013749 Tetrachlorodibenzodioxin C032668 1-nitropyrene C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D015124 8-Bromo Cyclic Adenosine Monophosphate D000643 Ammonium Chloride D019327 Copper Sulfate D005419 Flavonoids C568608 PCI 5002 more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 0.49 RPKM in Adrenal Gland Total median expression: 7.80 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-5.90	21	-0.281	Picture	PostScript	Text
3' UTR	-710.20	3053	-0.233	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR005301 - Mob1_phocein

Pfam Domains:
PF03637 - Mob1/phocein family

SCOP Domains:
101152 - Mob1/phocein

ModBase Predicted Comparative 3D Structure on Q9Y3A3


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0046872 metal ion binding Cellular Component: GO:0005737 cytoplasm GO:0005794 Golgi apparatus GO:0016020 membrane GO:0032580 Golgi cisterna membrane GO:0048471 perinuclear region of cytoplasm

Descriptions from all associated GenBank mRNAs


	AK289377 - Homo sapiens cDNA FLJ76596 complete cds, highly similar to Homo sapiens preimplantation protein 3 (PREI3), transcript variant 2, mRNA. AF250319 - Homo sapiens CGI95-iso mRNA, complete cds. BC005237 - Homo sapiens MOB1, Mps One Binder kinase activator-like 3 (yeast), mRNA (cDNA clone MGC:12264 IMAGE:3996585), complete cds. LF383606 - JP 2014500723-A/191109: Polycomb-Associated Non-Coding RNAs. AK292938 - Homo sapiens cDNA FLJ78747 complete cds, highly similar to Homo sapiens preimplantation protein 3 (PREI3), transcript variant 1, mRNA. AK027043 - Homo sapiens cDNA: FLJ23390 fis, clone HEP17176. AF093825 - Homo sapiens 2C4D mRNA, complete cds. AF151853 - Homo sapiens CGI-95 protein mRNA, complete cds. AK307497 - Homo sapiens cDNA, FLJ97445. AL080070 - Homo sapiens mRNA; cDNA DKFZp564M112 (from clone DKFZp564M112); complete cds. AB015441 - Homo sapiens mRNA for Mob3, complete cds. AK297514 - Homo sapiens cDNA FLJ55109 complete cds, highly similar to Preimplantation protein 3. AK297294 - Homo sapiens cDNA FLJ52887 complete cds, highly similar to Preimplantation protein 3. CR457371 - Homo sapiens full open reading frame cDNA clone RZPDo834C1210D for gene PREI3, preimplantation protein 3; complete cds, incl. stopcodon. AB590538 - Synthetic construct DNA, clone: pFN21AB6914, Homo sapiens MOBKL3 gene for MOB1, Mps One Binder kinase activator-like 3, without stop codon, in Flexi system. AJ580638 - Homo sapiens mRNA for Mob1 protein (MOB1 gene). LF317765 - JP 2014500723-A/125268: Polycomb-Associated Non-Coding RNAs. LF317769 - JP 2014500723-A/125272: Polycomb-Associated Non-Coding RNAs. LF317770 - JP 2014500723-A/125273: Polycomb-Associated Non-Coding RNAs. JD315732 - Sequence 296756 from Patent EP1572962. JD357703 - Sequence 338727 from Patent EP1572962. JD311407 - Sequence 292431 from Patent EP1572962. JD562563 - Sequence 543587 from Patent EP1572962. JD049964 - Sequence 30988 from Patent EP1572962. JD559823 - Sequence 540847 from Patent EP1572962. JD093423 - Sequence 74447 from Patent EP1572962. JD207115 - Sequence 188139 from Patent EP1572962. JD202747 - Sequence 183771 from Patent EP1572962. JD157604 - Sequence 138628 from Patent EP1572962. JD394103 - Sequence 375127 from Patent EP1572962. JD244400 - Sequence 225424 from Patent EP1572962. JD292820 - Sequence 273844 from Patent EP1572962. JD183744 - Sequence 164768 from Patent EP1572962. JD168273 - Sequence 149297 from Patent EP1572962. JD214057 - Sequence 195081 from Patent EP1572962. JD286265 - Sequence 267289 from Patent EP1572962. LF317771 - JP 2014500723-A/125274: Polycomb-Associated Non-Coding RNAs. JD431774 - Sequence 412798 from Patent EP1572962. JD078405 - Sequence 59429 from Patent EP1572962. JD486634 - Sequence 467658 from Patent EP1572962. MA619183 - JP 2018138019-A/191109: Polycomb-Associated Non-Coding RNAs. MA553342 - JP 2018138019-A/125268: Polycomb-Associated Non-Coding RNAs. MA553346 - JP 2018138019-A/125272: Polycomb-Associated Non-Coding RNAs. MA553347 - JP 2018138019-A/125273: Polycomb-Associated Non-Coding RNAs. MA553348 - JP 2018138019-A/125274: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: B4DML0, CGI-95, ENST00000323303.1, ENST00000323303.2, ENST00000323303.3, ENST00000323303.4, ENST00000323303.5, ENST00000323303.6, ENST00000323303.7, ENST00000323303.8, MOB3, MOBKL3, NM_015387, PHOCN, PHOCN_HUMAN, PREI3, Q53SE0, Q7Z4Y6, Q9H2P3, Q9H5J1, Q9Y3A3, Q9Y4T8, uc317rla.1, uc317rla.2 UCSC ID: ENST00000323303.9_4 RefSeq Accession: NM_015387.5 Protein: Q9Y3A3 (aka PHOCN_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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