ID:MPH6_HUMAN DESCRIPTION: RecName: Full=M-phase phosphoprotein 6; FUNCTION: RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D. SUBUNIT: Associates with the RNA exosome complex, probably mediated by EXOSC10. Interacts with ARHGAP18, EXOSC10 and SKIV2L2. INTERACTION: Q01780:EXOSC10; NbExp=4; IntAct=EBI-373187, EBI-358236; Q13868:EXOSC2; NbExp=3; IntAct=EBI-373187, EBI-301735; P42285:SKIV2L2; NbExp=2; IntAct=EBI-373187, EBI-347612; SUBCELLULAR LOCATION: Nucleus, nucleolus. Cytoplasm. Note=Cytoplasmic in M phase. PTM: Phosphorylated in M (mitotic) phase. SIMILARITY: Belongs to the MPP6 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99547
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
