ID:RM18_HUMAN DESCRIPTION: RecName: Full=39S ribosomal protein L18, mitochondrial; Short=L18mt; Short=MRP-L18; Flags: Precursor; FUNCTION: Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA. SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the ribosomal protein L18P family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H0U6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK311391 - Homo sapiens cDNA, FLJ18433. AF161556 - Homo sapiens HSPC071 mRNA, complete cds. BC001623 - Homo sapiens mitochondrial ribosomal protein L18, mRNA (cDNA clone MGC:777 IMAGE:3357333), complete cds. AL136633 - Homo sapiens mRNA; cDNA DKFZp564H012 (from clone DKFZp564H012). JD265593 - Sequence 246617 from Patent EP1572962. AK292647 - Homo sapiens cDNA FLJ76688 complete cds, highly similar to Homo sapiens HSPC071 mRNA. JD257519 - Sequence 238543 from Patent EP1572962. AB528185 - Synthetic construct DNA, clone: pF1KE0139, Homo sapiens MRPL18 gene for mitochondrial ribosomal protein L18, without stop codon, in Flexi system. AM393775 - Synthetic construct Homo sapiens clone IMAGE:100002078 for hypothetical protein (MRPL18 gene). KJ898708 - Synthetic construct Homo sapiens clone ccsbBroadEn_08102 MRPL18 gene, encodes complete protein. CR533491 - Homo sapiens full open reading frame cDNA clone RZPDo834D1117D for gene MRPL18, mitochondrial ribosomal protein L18; complete cds, incl. stopcodon. LF340243 - JP 2014500723-A/147746: Polycomb-Associated Non-Coding RNAs. MA575820 - JP 2018138019-A/147746: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9H0U6 (Reactome details) participates in the following event(s):
R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation) R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA R-HSA-5368286 Mitochondrial translation initiation R-HSA-5419276 Mitochondrial translation termination R-HSA-5368287 Mitochondrial translation R-HSA-5389840 Mitochondrial translation elongation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
