Human Gene MRPS11 (ENST00000325844.9_4) from GENCODE V47lift37

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Description: mitochondrial ribosomal protein S11, transcript variant 10 (from RefSeq NR_135918.2)
Gencode Transcript: ENST00000325844.9_4
Gencode Gene: ENSG00000181991.16_7
Transcript (Including UTRs)
Position: hg19 chr15:89,010,939-89,024,007 Size: 13,069 Total Exon Count: 6 Strand: +
Coding Region
Position: hg19 chr15:89,010,949-89,021,210 Size: 10,262 Coding Exon Count: 6

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr15:89,010,939-89,024,007)			mRNA (may differ from genome)		Protein (194 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RT11_HUMAN DESCRIPTION: RecName: Full=28S ribosomal protein S11, mitochondrial; Short=MRP-S11; Short=S11mt; AltName: Full=Cervical cancer proto-oncogene 2 protein; Short=HCC-2; Flags: Precursor; SUBUNIT: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the ribosomal protein S11P family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C014211 2,3,7,8-tetrachlorodibenzofuran D000082 Acetaminophen D001564 Benzo(a)pyrene D019256 Cadmium Chloride D019327 Copper Sulfate D003993 Dibutyl Phthalate D015741 Metribolone D010433 Pentylenetetrazole D012999 Soman D013749 Tetrachlorodibenzodioxin more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 19.08 RPKM in Adrenal Gland Total median expression: 578.07 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
3' UTR	-1078.25	2797	-0.386	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001971 - Ribosomal_S11
IPR018102 - Ribosomal_S11_CS

Pfam Domains:
PF00411 - Ribosomal protein S11

SCOP Domains:
53137 - Translational machinery components

ModBase Predicted Comparative 3D Structure on P82912


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003723 RNA binding GO:0003735 structural constituent of ribosome GO:0048027 mRNA 5'-UTR binding GO:0070181 small ribosomal subunit rRNA binding Biological Process: GO:0000028 ribosomal small subunit assembly GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0006412 translation GO:0032543 mitochondrial translation GO:0042769 DNA damage response, detection of DNA damage GO:0070125 mitochondrial translational elongation GO:0070126 mitochondrial translational termination Cellular Component: GO:0005739 mitochondrion GO:0005743 mitochondrial inner membrane GO:0005763 mitochondrial small ribosomal subunit GO:0005840 ribosome

Descriptions from all associated GenBank mRNAs


	LF207726 - JP 2014500723-A/15229: Polycomb-Associated Non-Coding RNAs. AB049944 - Homo sapiens MRPS11 mRNA for mitochondrial ribosomal protein S11, complete cds. LF213741 - JP 2014500723-A/21244: Polycomb-Associated Non-Coding RNAs. BC032378 - Homo sapiens mitochondrial ribosomal protein S11, mRNA (cDNA clone MGC:40231 IMAGE:5110633), complete cds. BC012489 - Homo sapiens mitochondrial ribosomal protein S11, mRNA (cDNA clone MGC:22144 IMAGE:4452949), complete cds. AK027059 - Homo sapiens cDNA: FLJ23406 fis, clone HEP19309. AK315407 - Homo sapiens cDNA, FLJ96456, Homo sapiens mitochondrial ribosomal protein S11 (MRPS11), nucleargene encoding mitochondrial protein, transcript variant 1, mRNA. AK026165 - Homo sapiens cDNA: FLJ22512 fis, clone HRC11839. AK222933 - Homo sapiens mRNA for mitochondrial ribosomal protein S11 isoform a variant, clone: HRC11839. AK223152 - Homo sapiens mRNA for mitochondrial ribosomal protein S11 isoform a variant, clone: LNG01827. BC000200 - Homo sapiens mitochondrial ribosomal protein S11, mRNA (cDNA clone IMAGE:3352526), with apparent retained intron. CU680342 - Synthetic construct Homo sapiens gateway clone IMAGE:100020230 5' read MRPS11 mRNA. DQ891586 - Synthetic construct clone IMAGE:100004216; FLH178375.01X; RZPDo839C06128D mitochondrial ribosomal protein S11 (MRPS11) gene, encodes complete protein; nuclear gene for mitochondrial product. DQ894780 - Synthetic construct Homo sapiens clone IMAGE:100009240; FLH178371.01L; RZPDo839C06127D mitochondrial ribosomal protein S11 (MRPS11) gene, encodes complete protein; nuclear gene for mitochondrial product. CU689362 - Synthetic construct Homo sapiens gateway clone IMAGE:100023294 5' read MRPS11 mRNA. KJ894596 - Synthetic construct Homo sapiens clone ccsbBroadEn_03990 MRPS11 gene, encodes complete protein. KJ903111 - Synthetic construct Homo sapiens clone ccsbBroadEn_12505 MRPS11 gene, encodes complete protein. BC009451 - Homo sapiens, clone IMAGE:3531918, mRNA, partial cds. LF368423 - JP 2014500723-A/175926: Polycomb-Associated Non-Coding RNAs. LF368427 - JP 2014500723-A/175930: Polycomb-Associated Non-Coding RNAs. DQ587547 - Homo sapiens piRNA piR-54659, complete sequence. JD190753 - Sequence 171777 from Patent EP1572962. JD472043 - Sequence 453067 from Patent EP1572962. JD193765 - Sequence 174789 from Patent EP1572962. JD203396 - Sequence 184420 from Patent EP1572962. JD420371 - Sequence 401395 from Patent EP1572962. JD338259 - Sequence 319283 from Patent EP1572962. JD102881 - Sequence 83905 from Patent EP1572962. JD550490 - Sequence 531514 from Patent EP1572962. LF368429 - JP 2014500723-A/175932: Polycomb-Associated Non-Coding RNAs. JD452576 - Sequence 433600 from Patent EP1572962. JD081606 - Sequence 62630 from Patent EP1572962. MA604000 - JP 2018138019-A/175926: Polycomb-Associated Non-Coding RNAs. MA604004 - JP 2018138019-A/175930: Polycomb-Associated Non-Coding RNAs. MA604006 - JP 2018138019-A/175932: Polycomb-Associated Non-Coding RNAs. MA443303 - JP 2018138019-A/15229: Polycomb-Associated Non-Coding RNAs. MA449318 - JP 2018138019-A/21244: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein P82912 (Reactome details) participates in the following event(s): R-HSA-5368279 MTIF3 binds 28S ribosomal subunit R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits R-HSA-5389849 28S subunit:MTIF3 binds MTIF2:GTP, mRNA, and formylMet-tRNA R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation) R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA R-HSA-5368286 Mitochondrial translation initiation R-HSA-5419276 Mitochondrial translation termination R-HSA-5368287 Mitochondrial translation R-HSA-5389840 Mitochondrial translation elongation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins

Other Names for This Gene


	Alternate Gene Symbols: B2RD52, ENST00000325844.1, ENST00000325844.2, ENST00000325844.3, ENST00000325844.4, ENST00000325844.5, ENST00000325844.6, ENST00000325844.7, ENST00000325844.8, HCC2, NR_135918, P82912, Q969D7, Q96GI3, Q9BYC3, RPMS11, RT11_HUMAN, uc317rxy.1, uc317rxy.2 UCSC ID: ENST00000325844.9_4 RefSeq Accession: NM_022839.5 Protein: P82912 (aka RT11_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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