Human Gene MRPS18B (ENST00000259873.5_4) from GENCODE V47lift37

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Description: mitochondrial ribosomal protein S18B (from RefSeq NM_014046.4)
Gencode Transcript: ENST00000259873.5_4
Gencode Gene: ENSG00000204568.12_7
Transcript (Including UTRs)
Position: hg19 chr6:30,585,617-30,594,169 Size: 8,553 Total Exon Count: 7 Strand: +
Coding Region
Position: hg19 chr6:30,585,643-30,593,574 Size: 7,932 Coding Exon Count: 7

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr6:30,585,617-30,594,169)			mRNA (may differ from genome)		Protein (258 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RT18B_HUMAN DESCRIPTION: RecName: Full=28S ribosomal protein S18b, mitochondrial; Short=MRP-S18-b; Short=Mrps18-b; Short=S18mt-b; AltName: Full=28S ribosomal protein S18-2, mitochondrial; Short=MRP-S18-2; Flags: Precursor; SUBUNIT: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. INTERACTION: Q9UBC1:NFKBIL1; NbExp=1; IntAct=EBI-750085, EBI-1043728; SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the ribosomal protein S18P family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C006780 bisphenol A C016403 2,4-dinitrotoluene C009505 4,4'-diaminodiphenylmethane C035207 4-amino-2,6-dinitrotoluene D000082 Acetaminophen D000638 Amiodarone D000639 Amitriptyline D019256 Cadmium Chloride D002995 Clofibric Acid D002997 Clomipramine more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 61.63 RPKM in Muscle - Skeletal Total median expression: 1459.92 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-1.70	26	-0.065	Picture	PostScript	Text
3' UTR	-196.00	595	-0.329	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001648 - Ribosomal_S18

Pfam Domains:
PF01084 - Ribosomal protein S18

SCOP Domains:
46911 - Ribosomal protein S18
52833 - Thioredoxin-like
57850 - RING/U-box

ModBase Predicted Comparative 3D Structure on Q9Y676


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003735 structural constituent of ribosome GO:0005515 protein binding Biological Process: GO:0006412 translation GO:0032543 mitochondrial translation GO:0070125 mitochondrial translational elongation GO:0070126 mitochondrial translational termination Cellular Component: GO:0005622 intracellular GO:0005654 nucleoplasm GO:0005739 mitochondrion GO:0005743 mitochondrial inner membrane GO:0005763 mitochondrial small ribosomal subunit GO:0005840 ribosome GO:0030054 cell junction

Descriptions from all associated GenBank mRNAs


	BC005373 - Homo sapiens mitochondrial ribosomal protein S18B, mRNA (cDNA clone MGC:12489 IMAGE:3933607), complete cds. AF151017 - Homo sapiens HSPC183 mRNA, complete cds. AK294086 - Homo sapiens cDNA FLJ54285 complete cds, highly similar to 28S ribosomal protein S18b, mitochondrial precursor. AL050361 - Homo sapiens mRNA; cDNA DKFZp564H0223 (from clone DKFZp564H0223). AK311890 - Homo sapiens cDNA, FLJ92156, Homo sapiens mitochondrial ribosomal protein S18B (MRPS18B),nuclear gene encoding mitochondrial protein, mRNA. AF100761 - Homo sapiens PTD017 mRNA, complete cds. AB463890 - Synthetic construct DNA, clone: pF1KB8234, Homo sapiens MRPS18B gene for mitochondrial ribosomal protein S18B, without stop codon, in Flexi system. KJ898702 - Synthetic construct Homo sapiens clone ccsbBroadEn_08096 MRPS18B gene, encodes complete protein. AK126124 - Homo sapiens cDNA FLJ44136 fis, clone THYMU2009157. JD064026 - Sequence 45050 from Patent EP1572962. JD210789 - Sequence 191813 from Patent EP1572962. JD362400 - Sequence 343424 from Patent EP1572962. JD564459 - Sequence 545483 from Patent EP1572962. JD558363 - Sequence 539387 from Patent EP1572962. JD319626 - Sequence 300650 from Patent EP1572962. JD117251 - Sequence 98275 from Patent EP1572962. JD425478 - Sequence 406502 from Patent EP1572962. JD425479 - Sequence 406503 from Patent EP1572962. JD482939 - Sequence 463963 from Patent EP1572962. JD481529 - Sequence 462553 from Patent EP1572962. JD180082 - Sequence 161106 from Patent EP1572962. JD211935 - Sequence 192959 from Patent EP1572962. JD241670 - Sequence 222694 from Patent EP1572962. JD247829 - Sequence 228853 from Patent EP1572962. JD326986 - Sequence 308010 from Patent EP1572962. JD447884 - Sequence 428908 from Patent EP1572962. JD085909 - Sequence 66933 from Patent EP1572962. JD076379 - Sequence 57403 from Patent EP1572962. JD211129 - Sequence 192153 from Patent EP1572962. JD462331 - Sequence 443355 from Patent EP1572962. JD141771 - Sequence 122795 from Patent EP1572962. JD536021 - Sequence 517045 from Patent EP1572962. JD453813 - Sequence 434837 from Patent EP1572962. JD375050 - Sequence 356074 from Patent EP1572962. JD346188 - Sequence 327212 from Patent EP1572962. JD491797 - Sequence 472821 from Patent EP1572962. JD512579 - Sequence 493603 from Patent EP1572962. JD097572 - Sequence 78596 from Patent EP1572962. JD051042 - Sequence 32066 from Patent EP1572962. JD365772 - Sequence 346796 from Patent EP1572962. JD054900 - Sequence 35924 from Patent EP1572962. JD220054 - Sequence 201078 from Patent EP1572962. JD449919 - Sequence 430943 from Patent EP1572962. JD048359 - Sequence 29383 from Patent EP1572962. JD479515 - Sequence 460539 from Patent EP1572962. JD545425 - Sequence 526449 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9Y676 (Reactome details) participates in the following event(s): R-HSA-5368279 MTIF3 binds 28S ribosomal subunit R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits R-HSA-5389849 28S subunit:MTIF3 binds MTIF2:GTP, mRNA, and formylMet-tRNA R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation) R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA R-HSA-5368286 Mitochondrial translation initiation R-HSA-5419276 Mitochondrial translation termination R-HSA-5368287 Mitochondrial translation R-HSA-5389840 Mitochondrial translation elongation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins

Other Names for This Gene


	Alternate Gene Symbols: A6NDQ0, C6orf14, ENST00000259873.1, ENST00000259873.2, ENST00000259873.3, ENST00000259873.4, HSPC183, NM_014046, PTD017, Q659G4, Q9BS27, Q9Y676, RT18B_HUMAN, uc317ghy.1, uc317ghy.2 UCSC ID: ENST00000259873.5_4 RefSeq Accession: NM_014046.4 Protein: Q9Y676 (aka RT18B_HUMAN or R18B_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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