Human Gene MRPS34 (ENST00000397375.7_7) from GENCODE V47lift37
Description: mitochondrial ribosomal protein S34, transcript variant 2 (from RefSeq NM_023936.2)Gencode Transcript: ENST00000397375.7_7Gencode Gene: ENSG00000074071.15_9Transcript (Including UTRs) Position: hg19 chr16:1,821,896-1,823,135 Size: 1,240 Total Exon Count: 3 Strand: -Coding Region Position: hg19 chr16:1,822,222-1,823,120 Size: 899 Coding Exon Count: 3
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: RT34_HUMAN DESCRIPTION: RecName: Full=28S ribosomal protein S34, mitochondrial; Short=MRP-S34; Short=S34mt;SUBUNIT: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.SUBCELLULAR LOCATION: Mitochondrion.
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF16053 - Mitochondrial 28S ribosomal protein S34ModBase Predicted Comparative 3D Structure on P82930 The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF210734 - JP 2014500723-A/18237: Polycomb-Associated Non-Coding RNAs.BC001182 - Homo sapiens mitochondrial ribosomal protein S34, mRNA (cDNA clone MGC:2616 IMAGE:3357266), complete cds.JD447930 - Sequence 428954 from Patent EP1572962.JD537126 - Sequence 518150 from Patent EP1572962.JD124255 - Sequence 105279 from Patent EP1572962.JD320579 - Sequence 301603 from Patent EP1572962.JD526786 - Sequence 507810 from Patent EP1572962.JD537683 - Sequence 518707 from Patent EP1572962.JD485399 - Sequence 466423 from Patent EP1572962.JD055010 - Sequence 36034 from Patent EP1572962.JD538497 - Sequence 519521 from Patent EP1572962.JF432468 - Synthetic construct Homo sapiens clone IMAGE:100073689 mitochondrial ribosomal protein S34 (MRPS34) gene, encodes complete protein.KJ894611 - Synthetic construct Homo sapiens clone ccsbBroadEn_04005 MRPS34 gene, encodes complete protein.AB527721 - Synthetic construct DNA, clone: pF1KB6912, Homo sapiens MRPS34 gene for mitochondrial ribosomal protein S34, without stop codon, in Flexi system.LF340763 - JP 2014500723-A/148266: Polycomb-Associated Non-Coding RNAs.LF340762 - JP 2014500723-A/148265: Polycomb-Associated Non-Coding RNAs.EF036486 - Homo sapiens mitochondrial 28S ribosomal protein S34 mRNA, complete cds; nuclear gene for mitochondrial product.MA446311 - JP 2018138019-A/18237: Polycomb-Associated Non-Coding RNAs.MA576340 - JP 2018138019-A/148266: Polycomb-Associated Non-Coding RNAs.MA576339 - JP 2018138019-A/148265: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO) Reactome details) participates in the following event(s):R-HSA-5368279 MTIF3 binds 28S ribosomal subunitR-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunitsR-HSA-5389849 28S subunit:MTIF3 binds MTIF2:GTP, mRNA, and formylMet-tRNAR-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNAR-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNAR-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation)R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosomeR-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTPR-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNAR-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNAR-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNAR-HSA-5368286 Mitochondrial translation initiationR-HSA-5419276 Mitochondrial translation terminationR-HSA-5368287 Mitochondrial translationR-HSA-5389840 Mitochondrial translation elongationR-HSA-72766 TranslationR-HSA-392499 Metabolism of proteins
Other Names for This Gene
Alternate Gene Symbols: ENST00000397375.1, ENST00000397375.2, ENST00000397375.3, ENST00000397375.4, ENST00000397375.5, ENST00000397375.6, NM_023936, P82930, Q9BVI7, RT34_HUMAN, uc318yyu.1, uc318yyu.2UCSC ID: ENST00000397375.7_7RefSeq Accession: NM_023936.2 Protein: P82930
(aka RT34_HUMAN)
GeneReviews for This Gene
GeneReviews article(s) related to gene MRPS34:leigh-nucl-ov
Gene Model Information
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Methods, Credits, and Use Restrictions
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US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
