Human Gene MSL2 (ENST00000309993.3_7) from GENCODE V47lift37
  Description: MSL complex subunit 2, transcript variant 1 (from RefSeq NM_018133.4)
Gencode Transcript: ENST00000309993.3_7
Gencode Gene: ENSG00000174579.5_11
Transcript (Including UTRs)
   Position: hg19 chr3:135,867,759-135,915,177 Size: 47,419 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr3:135,869,989-135,913,955 Size: 43,967 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:135,867,759-135,915,177)mRNA (may differ from genome)Protein (577 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MSL2_HUMAN
DESCRIPTION: RecName: Full=Male-specific lethal 2 homolog; Short=MSL-2; AltName: Full=Male-specific lethal 2-like 1; Short=MSL2-like 1; AltName: Full=Male-specific lethal-2 homolog 1; AltName: Full=RING finger protein 184;
FUNCTION: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure.
SUBUNIT: Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/MYST1, MSL1/hampin, MSL2 and MSL3.
SIMILARITY: Belongs to the MSL2 family.
SIMILARITY: Contains 1 RING-type zinc finger.
SEQUENCE CAUTION: Sequence=AAH32719.1; Type=Erroneous initiation; Sequence=BAA91673.1; Type=Erroneous initiation; Sequence=BAB13411.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.23 RPKM in Spleen
Total median expression: 325.92 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -638.501222-0.523 Picture PostScript Text
3' UTR -558.502230-0.250 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001841 - Znf_RING

Pfam Domains:
PF16682 - CXC domain of E3 ubiquitin-protein ligase MSL2
PF16685 - zinc RING finger of MSL2

SCOP Domains:
57850 - RING/U-box

ModBase Predicted Comparative 3D Structure on Q9HCI7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity

Biological Process:
GO:0016567 protein ubiquitination
GO:0043984 histone H4-K16 acetylation

Cellular Component:
GO:0005654 nucleoplasm
GO:0072487 MSL complex


-  Descriptions from all associated GenBank mRNAs
  KJ894146 - Synthetic construct Homo sapiens clone ccsbBroadEn_03540 MSL2 gene, encodes complete protein.
AB046805 - Homo sapiens KIAA1585 mRNA for KIAA1585 protein.
AK001408 - Homo sapiens cDNA FLJ10546 fis, clone NT2RP2001721.
BC032719 - Homo sapiens male-specific lethal 2 homolog (Drosophila), mRNA (cDNA clone IMAGE:5517857), partial cds.
AL834289 - Homo sapiens mRNA; cDNA DKFZp667I1211 (from clone DKFZp667I1211).
JD427292 - Sequence 408316 from Patent EP1572962.
JD436352 - Sequence 417376 from Patent EP1572962.
JD112571 - Sequence 93595 from Patent EP1572962.
JD093496 - Sequence 74520 from Patent EP1572962.
JD405322 - Sequence 386346 from Patent EP1572962.
JD103542 - Sequence 84566 from Patent EP1572962.
JD306047 - Sequence 287071 from Patent EP1572962.
JD286132 - Sequence 267156 from Patent EP1572962.
JD427285 - Sequence 408309 from Patent EP1572962.
JD304702 - Sequence 285726 from Patent EP1572962.
AK302491 - Homo sapiens cDNA FLJ54913 complete cds, highly similar to Homo sapiens ring finger protein 184 (RNF184), mRNA.
JD202774 - Sequence 183798 from Patent EP1572962.
AK292557 - Homo sapiens cDNA FLJ76454 complete cds, highly similar to Homo sapiens ring finger protein 184 (RNF184), mRNA.
JD038676 - Sequence 19700 from Patent EP1572962.
JD504791 - Sequence 485815 from Patent EP1572962.
BC093790 - Homo sapiens male-specific lethal 2 homolog (Drosophila), mRNA (cDNA clone MGC:120825 IMAGE:7939635), complete cds.
BC093764 - Homo sapiens male-specific lethal 2 homolog (Drosophila), mRNA (cDNA clone MGC:120799 IMAGE:7939609), complete cds.
AB384243 - Synthetic construct DNA, clone: pF1KSDA1585, Homo sapiens MSL2L1 gene for ring finger protein 184, complete cds, without stop codon, in Flexi system.
AK091956 - Homo sapiens cDNA FLJ34637 fis, clone KIDNE2016142, weakly similar to MALE-SPECIFIC LETHAL-2 PROTEIN.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9HCI7 (Reactome details) participates in the following event(s):

R-HSA-3321883 MSL acetylates histone H4
R-HSA-3214847 HATs acetylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization

-  Other Names for This Gene
  Alternate Gene Symbols: B4DYL4, ENST00000309993.1, ENST00000309993.2, G5E9I1, KIAA1585, MSL2L1, MSL2_HUMAN, NM_018133, Q0D2P1, Q8NDB4, Q9HCI7, Q9NVS4, RNF184, uc317oqv.1, uc317oqv.2
UCSC ID: ENST00000309993.3_7
RefSeq Accession: NM_018133.4
Protein: Q9HCI7 (aka MSL2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.