ID:MY18B_HUMAN DESCRIPTION: RecName: Full=Unconventional myosin-XVIIIb; FUNCTION: May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. SUBUNIT: Homodimer. May interact with F actin through the GPA motif (Gly/Pro/Ala-rich). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere. Note=Punctate pattern in undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes. TISSUE SPECIFICITY: Selectively expressed in cardiac and skeletal muscles. Weakly expressed in testis, pancreas, placenta, prostate, lung and thymus. DEVELOPMENTAL STAGE: Reaches an expression peak in the third day after induction and remains at similar level during successive myotubule maturation. MISCELLANEOUS: Frequently deleted, mutated, and hypermethylated in lung cancers. SIMILARITY: Contains 1 IQ domain. SIMILARITY: Contains 1 myosin head-like domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IUG5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
