ID:NDUA7_HUMAN DESCRIPTION: RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7; AltName: Full=Complex I-B14.5a; Short=CI-B14.5a; AltName: Full=NADH-ubiquinone oxidoreductase subunit B14.5a; FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. SUBUNIT: Complex I is composed of 45 different subunits. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. SIMILARITY: Belongs to the complex I NDUFA7 subunit family. SEQUENCE CAUTION: Sequence=AAC99399.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95182
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006120 mitochondrial electron transport, NADH to ubiquinone GO:0032543 mitochondrial translation GO:0032981 mitochondrial respiratory chain complex I assembly GO:0042773 ATP synthesis coupled electron transport GO:0055114 oxidation-reduction process
BC003102 - Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa, mRNA (cDNA clone MGC:1877 IMAGE:3537231), complete cds. AF054178 - Homo sapiens CI-B14.5a homolog mRNA, complete cds. BC107892 - Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa, mRNA (cDNA clone IMAGE:6725622), partial cds. AF050637 - Homo sapiens NADH-ubiquinone oxidoreductase B14.5A subunit mRNA, nuclear gene encoding mitochondrial protein, complete cds. KJ891673 - Synthetic construct Homo sapiens clone ccsbBroadEn_01067 NDUFA7 gene, encodes complete protein. CR542266 - Homo sapiens full open reading frame cDNA clone RZPDo834G0326D for gene NDUFA7, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa; complete cds, without stopcodon. CR456915 - Homo sapiens full open reading frame cDNA clone RZPDo834G1015D for gene NDUFA7, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa; complete cds, incl. stopcodon.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-3781 - aerobic respiration I (cytochrome c)
Reactome (by CSHL, EBI, and GO)
Protein O95182 (Reactome details) participates in the following event(s):
R-HSA-6799178 Intermediate 1 binds HP subcomplex to form Intermediate 2 R-HSA-6799191 Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex R-HSA-6799202 The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex R-HSA-6799197 ND4, ND5 bind the 550kDa complex to form the 815kDa complex R-HSA-6799179 Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex R-HSA-6799196 The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I R-HSA-163217 Complex I oxidises NADH to NAD+, reduces CoQ to QH2 R-HSA-6799198 Complex I biogenesis R-HSA-611105 Respiratory electron transport R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
