ID:NEDD1_HUMAN DESCRIPTION: RecName: Full=Protein NEDD1; AltName: Full=Neural precursor cell expressed developmentally down-regulated protein 1; Short=NEDD-1; FUNCTION: Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. SUBUNIT: Interacts with FAM29A and gamma-tubulin. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. PTM: During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397, Ser-426 and Ser-637. Phosphorylated NEDD1 can interact with gamma- tubulin for targeting the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. SIMILARITY: Contains 8 WD repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NHV4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK290058 - Homo sapiens cDNA FLJ75002 complete cds, highly similar to Homo sapiens, neural precursor cell expressed,developmentally down-regulated gene 1. BC026168 - Homo sapiens neural precursor cell expressed, developmentally down-regulated 1, mRNA (cDNA clone IMAGE:4825704), with apparent retained intron. AK303656 - Homo sapiens cDNA FLJ58662 complete cds, highly similar to Protein NEDD1. AK315821 - Homo sapiens cDNA, FLJ79470 complete cds, highly similar to Protein NEDD1. AL832466 - Homo sapiens mRNA; cDNA DKFZp313N211 (from clone DKFZp313N211). BC020799 - Homo sapiens neural precursor cell expressed, developmentally down-regulated 1, mRNA (cDNA clone IMAGE:4248253), partial cds. AK093221 - Homo sapiens cDNA FLJ35902 fis, clone TESTI2009577, highly similar to NEDD1 PROTEIN. AX747997 - Sequence 1522 from Patent EP1308459. BC027605 - Homo sapiens neural precursor cell expressed, developmentally down-regulated 1, mRNA (cDNA clone MGC:26881 IMAGE:4827191), complete cds. FW420958 - A use of PSMA7, NEDD1, and RAE1 as the gene expression suppressant. JD461170 - Sequence 442194 from Patent EP1572962. DQ891606 - Synthetic construct clone IMAGE:100004236; FLH178577.01X; RZPDo839E09128D neural precursor cell expressed, developmentally down-regulated 1 (NEDD1) gene, encodes complete protein. DQ894799 - Synthetic construct Homo sapiens clone IMAGE:100009259; FLH178573.01L; RZPDo839E09127D neural precursor cell expressed, developmentally down-regulated 1 (NEDD1) gene, encodes complete protein. KJ895357 - Synthetic construct Homo sapiens clone ccsbBroadEn_04751 NEDD1 gene, encodes complete protein. AL832468 - Homo sapiens mRNA; cDNA DKFZp313A0321 (from clone DKFZp313A0321). LF360266 - JP 2014500723-A/167769: Polycomb-Associated Non-Coding RNAs. LF207023 - JP 2014500723-A/14526: Polycomb-Associated Non-Coding RNAs. LF360265 - JP 2014500723-A/167768: Polycomb-Associated Non-Coding RNAs. LF360264 - JP 2014500723-A/167767: Polycomb-Associated Non-Coding RNAs. JD066364 - Sequence 47388 from Patent EP1572962. JD552679 - Sequence 533703 from Patent EP1572962. JD566049 - Sequence 547073 from Patent EP1572962. MA595843 - JP 2018138019-A/167769: Polycomb-Associated Non-Coding RNAs. MA442600 - JP 2018138019-A/14526: Polycomb-Associated Non-Coding RNAs. MA595842 - JP 2018138019-A/167768: Polycomb-Associated Non-Coding RNAs. MA595841 - JP 2018138019-A/167767: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8NHV4 (Reactome details) participates in the following event(s):
R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome R-HSA-380272 Plk1-mediated phosphorylation of Nlp R-HSA-380294 Loss of C-Nap-1 from centrosomes R-HSA-380311 Recruitment of Plk1 to centrosomes R-HSA-380455 Recruitment of CDK11p58 to the centrosomes R-HSA-380303 Dissociation of Phospho-Nlp from the centrosome R-HSA-5626220 C2CD3 binds the mother centriole R-HSA-380508 Translocation of NuMA to the centrosomes R-HSA-2574845 AJUBA binds centrosome-associated AURKA R-HSA-8853405 TPX2 binds AURKA at centrosomes R-HSA-3000319 BORA binds PLK1 and AURKA R-HSA-2574840 AJUBA facilitates AURKA autophosphorylation R-HSA-3000310 AURKA phosphorylates PLK1 R-HSA-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole R-HSA-5626681 Recruitment of transition zone proteins R-HSA-5626227 CP110 and CEP97 dissociate from the centriole R-HSA-380316 Association of NuMA with microtubules R-HSA-8853419 TPX2 promotes AURKA autophosphorylation R-HSA-5626228 The distal appendage proteins recruit TTBK2 R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body R-HSA-5626699 MARK4 binds ODF2 in the centriole R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-380287 Centrosome maturation R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-8854518 AURKA Activation by TPX2 R-HSA-5617833 Cilium Assembly R-HSA-68877 Mitotic Prometaphase R-HSA-69275 G2/M Transition R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-68886 M Phase R-HSA-453274 Mitotic G2-G2/M phases R-HSA-69278 Cell Cycle (Mitotic) R-HSA-1640170 Cell Cycle
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Common Gene Haplotype Alleles 
