Human Gene NOL3 (ENST00000564992.2_7) from GENCODE V47lift37

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Description: nucleolar protein 3, transcript variant 2 (from RefSeq NM_003946.7)
Gencode Transcript: ENST00000564992.2_7
Gencode Gene: ENSG00000140939.15_16
Transcript (Including UTRs)
Position: hg19 chr16:67,204,441-67,209,640 Size: 5,200 Total Exon Count: 4 Strand: +
Coding Region
Position: hg19 chr16:67,208,073-67,208,957 Size: 885 Coding Exon Count: 3

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr16:67,204,441-67,209,640)			mRNA (may differ from genome)		Protein (208 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: NOL3 Diseases sorted by gene-association score: myoclonus, familial cortical* (1679), myoclonus (15) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D001564 Benzo(a)pyrene D000431 Ethanol C029141 2,2,5,7,8-pentamethyl-1-hydroxychroman C014024 2,4,5,2',4',5'-hexachlorobiphenyl C016403 2,4-dinitrotoluene C023514 2,6-dinitrotoluene C009505 4,4'-diaminodiphenylmethane C547126 AZM551248 D000450 Aldosterone more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 26.27 RPKM in Prostate Total median expression: 593.86 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-5.70	45	-0.127	Picture	PostScript	Text
3' UTR	-237.90	683	-0.348	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001315 - CARD
IPR011029 - DEATH-like

Pfam Domains:
PF00619 - Caspase recruitment domain

SCOP Domains:
47986 - DEATH domain

ModBase Predicted Comparative 3D Structure on Q5TZN6


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Biological Process: GO:0042981 regulation of apoptotic process

Descriptions from all associated GenBank mRNAs


	LF212228 - JP 2014500723-A/19731: Polycomb-Associated Non-Coding RNAs. AK294145 - Homo sapiens cDNA FLJ58768 complete cds, highly similar to Homo sapiens nucleolar protein 3 (apoptosis repressor with CARD domain) (NOL3), mRNA. AK092623 - Homo sapiens cDNA FLJ35304 fis, clone PROST2009731. AX747633 - Sequence 1158 from Patent EP1308459. AF043244 - Homo sapiens apoptosis repressor ARC (ARC) mRNA, complete cds. AK314899 - Homo sapiens cDNA, FLJ95803, Homo sapiens nucleolar protein 3 (apoptosis repressor with CARD domain) (NOL3), mRNA. BC012798 - Homo sapiens nucleolar protein 3 (apoptosis repressor with CARD domain), mRNA (cDNA clone MGC:2009 IMAGE:3506011), complete cds. AF064600 - Homo sapiens cytoplasmic protein Myp (NOP) mRNA, alternatively spliced, complete cds. AF064599 - Homo sapiens nucleolar protein Nop30 (NOP) mRNA, alternatively spliced, complete cds. BT020158 - Homo sapiens nucleolar protein 3 (apoptosis repressor with CARD domain) mRNA, complete cds. DQ893049 - Synthetic construct clone IMAGE:100005679; FLH193056.01X; RZPDo839C0678D nucleolar protein 3 (apoptosis repressor with CARD domain) (NOL3) gene, encodes complete protein. DQ896297 - Synthetic construct Homo sapiens clone IMAGE:100010757; FLH193052.01L; RZPDo839C0668D nucleolar protein 3 (apoptosis repressor with CARD domain) (NOL3) gene, encodes complete protein. JD075398 - Sequence 56422 from Patent EP1572962. JD128706 - Sequence 109730 from Patent EP1572962. JD227786 - Sequence 208810 from Patent EP1572962. JD256333 - Sequence 237357 from Patent EP1572962. JD218126 - Sequence 199150 from Patent EP1572962. JD480825 - Sequence 461849 from Patent EP1572962. JD467631 - Sequence 448655 from Patent EP1572962. JD078088 - Sequence 59112 from Patent EP1572962. JD079673 - Sequence 60697 from Patent EP1572962. JD048257 - Sequence 29281 from Patent EP1572962. JD137343 - Sequence 118367 from Patent EP1572962. JD145850 - Sequence 126874 from Patent EP1572962. JD322406 - Sequence 303430 from Patent EP1572962. JD110743 - Sequence 91767 from Patent EP1572962. JD403347 - Sequence 384371 from Patent EP1572962. JD441832 - Sequence 422856 from Patent EP1572962. JD250574 - Sequence 231598 from Patent EP1572962. JD563016 - Sequence 544040 from Patent EP1572962. JD504082 - Sequence 485106 from Patent EP1572962. JD548390 - Sequence 529414 from Patent EP1572962. JD526542 - Sequence 507566 from Patent EP1572962. MA447805 - JP 2018138019-A/19731: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000564992.1, hCG_28817 , NM_003946, NOL3 , Q5TZN6, Q5TZN6_HUMAN, uc325twg.1, uc325twg.2 UCSC ID: ENST00000564992.2_7 RefSeq Accession: NM_001276309.3 Protein: Q5TZN6

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.