Human Gene NUDT9 (ENST00000302174.9_8) from GENCODE V47lift37

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Description: nudix hydrolase 9, transcript variant 1 (from RefSeq NM_024047.5)
Gencode Transcript: ENST00000302174.9_8
Gencode Gene: ENSG00000170502.13_12
Transcript (Including UTRs)
Position: hg19 chr4:88,343,725-88,380,607 Size: 36,883 Total Exon Count: 8 Strand: +
Coding Region
Position: hg19 chr4:88,344,058-88,379,173 Size: 35,116 Coding Exon Count: 8

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr4:88,343,725-88,380,607)			mRNA (may differ from genome)		Protein (350 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: NUDT9_HUMAN DESCRIPTION: RecName: Full=ADP-ribose pyrophosphatase, mitochondrial; EC=3.6.1.13; AltName: Full=ADP-ribose diphosphatase; AltName: Full=ADP-ribose phosphohydrolase; AltName: Full=Adenosine diphosphoribose pyrophosphatase; Short=ADPR-PPase; AltName: Full=Nucleoside diphosphate-linked moiety X motif 9; Short=Nudix motif 9; Flags: Precursor; FUNCTION: Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'- phosphate. CATALYTIC ACTIVITY: ADP-ribose + H(2)O = AMP + D-ribose 5- phosphate. COFACTOR: Magnesium. COFACTOR: Manganese. SUBUNIT: Monomer. Interacts with C17orf25. SUBCELLULAR LOCATION: Isoform 1: Mitochondrion. TISSUE SPECIFICITY: Ubiquitously expressed but isoform 1 is the most predominant isoform. INDUCTION: Isoform 1 is inhibited by fluoride and N-acetyl-p- benzoquinoneimine. SIMILARITY: Belongs to the Nudix hydrolase family. NudF subfamily. SIMILARITY: Contains 1 nudix hydrolase domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: NUDT9 Diseases sorted by gene-association score: type 1 diabetes mellitus 10 (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D013749 Tetrachlorodibenzodioxin C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) C023514 2,6-dinitrotoluene D019256 Cadmium Chloride D002251 Carbon Tetrachloride D002994 Clofibrate D003300 Copper D016572 Cyclosporine D003993 Dibutyl Phthalate more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 16.24 RPKM in Adrenal Gland Total median expression: 510.13 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-131.90	333	-0.396	Picture	PostScript	Text
3' UTR	-328.20	1434	-0.229	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000086 - NUDIX_hydrolase_dom
IPR015797 - NUDIX_hydrolase_dom-like

Pfam Domains:
PF00293 - NUDIX domain

SCOP Domains:
55811 - Nudix

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1Q33 - X-ray MuPIT

1QVJ - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q9BW91


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0016787 hydrolase activity GO:0019144 ADP-sugar diphosphatase activity GO:0043262 adenosine-diphosphatase activity GO:0047631 ADP-ribose diphosphatase activity Biological Process: GO:0034656 nucleobase-containing small molecule catabolic process GO:0046032 ADP catabolic process GO:0046709 IDP catabolic process Cellular Component: GO:0005622 intracellular GO:0005739 mitochondrion GO:0005759 mitochondrial matrix GO:0070062 extracellular exosome

Descriptions from all associated GenBank mRNAs


	AK027295 - Homo sapiens cDNA FLJ14389 fis, clone HEMBA1002876. AK074845 - Homo sapiens cDNA FLJ90364 fis, clone NT2RP2004069. AF265341 - Homo sapiens putative nudix hydrolyase mRNA, complete cds. AF273028 - Homo sapiens NUDT10 mRNA, complete cds. AY026252 - Homo sapiens ADP-ribose pyrosphosphatase NUDT9 (NUDT9) mRNA, complete cds. AK075408 - Homo sapiens cDNA PSEC0099 fis, clone NT2RP2002907, highly similar to ADP-ribose pyrophosphatase (EC 3.6.1.13). JD143029 - Sequence 124053 from Patent EP1572962. JD509522 - Sequence 490546 from Patent EP1572962. JD318530 - Sequence 299554 from Patent EP1572962. AK308028 - Homo sapiens cDNA, FLJ97976. BC000542 - Homo sapiens nudix (nucleoside diphosphate linked moiety X)-type motif 9, mRNA (cDNA clone MGC:3037 IMAGE:3163944), complete cds. JD141655 - Sequence 122679 from Patent EP1572962. AY359123 - Homo sapiens clone DNA119498 NUDT9 (UNQ3012) mRNA, complete cds. JD310282 - Sequence 291306 from Patent EP1572962. CU674266 - Synthetic construct Homo sapiens gateway clone IMAGE:100018169 5' read NUDT9 mRNA. KJ893993 - Synthetic construct Homo sapiens clone ccsbBroadEn_03387 NUDT9 gene, encodes complete protein. JD121362 - Sequence 102386 from Patent EP1572962. JD327495 - Sequence 308519 from Patent EP1572962. JD082547 - Sequence 63571 from Patent EP1572962. JD503497 - Sequence 484521 from Patent EP1572962. DQ587127 - Homo sapiens piRNA piR-54239, complete sequence. DQ587128 - Homo sapiens piRNA piR-54240, complete sequence. DQ587130 - Homo sapiens piRNA piR-54242, complete sequence. JD437546 - Sequence 418570 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9BW91 (Reactome details) participates in the following event(s): R-HSA-2393954 Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP R-HSA-2393930 Phosphate bond hydrolysis by NUDT proteins R-HSA-74259 Purine catabolism R-HSA-8956319 Nucleobase catabolism R-HSA-15869 Metabolism of nucleotides R-HSA-1430728 Metabolism

Other Names for This Gene


	Alternate Gene Symbols: ENST00000302174.1, ENST00000302174.2, ENST00000302174.3, ENST00000302174.4, ENST00000302174.5, ENST00000302174.6, ENST00000302174.7, ENST00000302174.8, NM_024047, NUDT10, NUDT9_HUMAN, PSEC0099, Q8NBN1, Q8NCB9, Q8NG25, Q9BW91, uc317myx.1, uc317myx.2, UNQ3012/PRO9771 UCSC ID: ENST00000302174.9_8 RefSeq Accession: NM_024047.5 Protein: Q9BW91 (aka NUDT9_HUMAN or NUD9_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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