ID:NU107_HUMAN DESCRIPTION: RecName: Full=Nuclear pore complex protein Nup107; AltName: Full=107 kDa nucleoporin; AltName: Full=Nucleoporin Nup107; FUNCTION: Essential component of nuclear pore complex. Required for the assembly of peripheral proteins into the nuclear pore complex. SUBUNIT: Forms part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus. INTERACTION: Q8WUM0:NUP133; NbExp=5; IntAct=EBI-295687, EBI-295695; SUBCELLULAR LOCATION: Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Note=Located on both the cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the nucleoporin Nup84/Nup107 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P57740
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0017056 structural constituent of nuclear pore
Biological Process: GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery GO:0006355 regulation of transcription, DNA-templated GO:0006406 mRNA export from nucleus GO:0006606 protein import into nucleus GO:0008585 female gonad development GO:0015031 protein transport GO:0016032 viral process GO:0051028 mRNA transport GO:0051292 nuclear pore complex assembly
AJ295745 - Homo sapiens mRNA for nuclear pore complex protein (NUP107 gene). AK055629 - Homo sapiens cDNA FLJ31067 fis, clone HSYRA2001225, highly similar to Homo sapiens mRNA for nuclear pore complex protein. AK315157 - Homo sapiens cDNA, FLJ96130. AK094183 - Homo sapiens cDNA FLJ36864 fis, clone ASTRO2016044, highly similar to Homo sapiens mRNA for nuclear pore complex protein (NUP107 gene). BC017167 - Homo sapiens nucleoporin 107kDa, mRNA (cDNA clone MGC:9311 IMAGE:3909848), complete cds. BC043343 - Homo sapiens nucleoporin 107kDa, mRNA (cDNA clone MGC:49877 IMAGE:5785959), complete cds. JD095842 - Sequence 76866 from Patent EP1572962. JD039076 - Sequence 20100 from Patent EP1572962. AK302773 - Homo sapiens cDNA FLJ58739 complete cds, highly similar to Nuclear pore complex protein Nup107. BC017670 - Homo sapiens nucleoporin 107kDa, mRNA (cDNA clone IMAGE:3883934), partial cds. AK002079 - Homo sapiens cDNA FLJ11217 fis, clone PLACE1008044, highly similar to NUCLEAR PORE COMPLEX PROTEIN NUP107. JD280748 - Sequence 261772 from Patent EP1572962. JD140654 - Sequence 121678 from Patent EP1572962. JD198515 - Sequence 179539 from Patent EP1572962. JD153370 - Sequence 134394 from Patent EP1572962. JD161815 - Sequence 142839 from Patent EP1572962. JD547948 - Sequence 528972 from Patent EP1572962. JD547949 - Sequence 528973 from Patent EP1572962. JD228408 - Sequence 209432 from Patent EP1572962. JD525353 - Sequence 506377 from Patent EP1572962. JD415596 - Sequence 396620 from Patent EP1572962. JD252492 - Sequence 233516 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P57740 (Reactome details) participates in the following event(s):
R-HSA-75096 Docking of the TAP:EJC Complex with the NPC R-HSA-165043 Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC R-HSA-180622 Vpr binds nucleoporins R-HSA-180710 Rev:importin beta:B23 recruited to the nuclear pore R-HSA-2990882 CDK1 phosphorylates NUP98 R-HSA-75098 mRNP complex dissociates from cytosolic face of NPC R-HSA-165047 Translocation of nuclear RNA transport complex to cytoplasm R-HSA-180732 Translocation of Rev:importin-beta:B23 to the nucleus R-HSA-2990880 NEK6/NEK7 phosphorylates NUP98 R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-170796 NPC transports GCK1:GKRP from cytosol to nucleoplasm R-HSA-5578744 Importin-8 imports AGO2:miRNA into the nucleus R-HSA-6783483 tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol R-HSA-3000348 RANBP2 SUMOylates SP100 with SUMO2 R-HSA-3000399 RANBP2 SUMOylates SP100 with SUMO1 R-HSA-3000411 RANBP2 SUMOylates PML with SUMO2 R-HSA-4570493 RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 R-HSA-4615872 RANBP2 SUMOylates HDAC4 with SUMO1 R-HSA-4615987 RANBP2 SUMOylates HDAC4 with SUMO2,3 R-HSA-5228508 RANBP2 SUMOylates PML with SUMO1 R-HSA-5228525 RANBP2 SUMOylates TOP2A with SUMO1 R-HSA-192627 Viral mRNA Export R-HSA-192925 Export of Spliced Viral mRNA R-HSA-5252041 NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-165054 Rev-mediated nuclear export of HIV RNA R-HSA-180910 Vpr-mediated nuclear import of PICs R-HSA-180746 Nuclear import of Rev protein R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-72202 Transport of Mature Transcript to Cytoplasm R-HSA-162599 Late Phase of HIV Life Cycle R-HSA-177243 Interactions of Rev with host cellular proteins R-HSA-176033 Interactions of Vpr with host cellular proteins R-HSA-2980766 Nuclear Envelope Breakdown R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-168276 NS1 Mediated Effects on Host Pathways R-HSA-1169408 ISG15 antiviral mechanism R-HSA-5578749 Transcriptional regulation by small RNAs R-HSA-6784531 tRNA processing in the nucleus R-HSA-3108214 SUMOylation of DNA damage response and repair proteins R-HSA-4570464 SUMOylation of RNA binding proteins R-HSA-4551638 SUMOylation of chromatin organization proteins R-HSA-4615885 SUMOylation of DNA replication proteins R-HSA-168325 Viral Messenger RNA Synthesis R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-162587 HIV Life Cycle R-HSA-162909 Host Interactions of HIV factors R-HSA-68875 Mitotic Prophase R-HSA-70171 Glycolysis R-HSA-168253 Host Interactions with Influenza Factors R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes R-HSA-211000 Gene Silencing by RNA R-HSA-72306 tRNA processing R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins R-HSA-168273 Influenza Viral RNA Transcription and Replication R-HSA-3371556 Cellular response to heat stress R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-8953854 Metabolism of RNA R-HSA-162906 HIV Infection R-HSA-70326 Glucose metabolism R-HSA-168254 Influenza Infection R-HSA-913531 Interferon Signaling R-HSA-74160 Gene expression (Transcription) R-HSA-2990846 SUMOylation R-HSA-168255 Influenza Life Cycle R-HSA-2262752 Cellular responses to stress R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-162582 Signal Transduction R-HSA-5663205 Infectious disease R-HSA-71387 Metabolism of carbohydrates R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-597592 Post-translational protein modification R-HSA-8953897 Cellular responses to external stimuli R-HSA-1643685 Disease R-HSA-1430728 Metabolism R-HSA-168256 Immune System R-HSA-392499 Metabolism of proteins
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Common Gene Haplotype Alleles 
