Human Gene OSBPL10 (ENST00000396556.7_10) from GENCODE V47lift37

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Description: oxysterol binding protein like 10, transcript variant 1 (from RefSeq NM_017784.5)
Gencode Transcript: ENST00000396556.7_10
Gencode Gene: ENSG00000144645.16_19
Transcript (Including UTRs)
Position: hg19 chr3:31,702,317-32,022,754 Size: 320,438 Total Exon Count: 12 Strand: -
Coding Region
Position: hg19 chr3:31,703,564-32,022,671 Size: 319,108 Coding Exon Count: 12

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:31,702,317-32,022,754)			mRNA (may differ from genome)		Protein (764 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: OSB10_HUMAN DESCRIPTION: RecName: Full=Oxysterol-binding protein-related protein 10; Short=ORP-10; Short=OSBP-related protein 10; SIMILARITY: Belongs to the OSBP family. SIMILARITY: Contains 1 PH domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D001564 Benzo(a)pyrene D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D002945 Cisplatin D019327 Copper Sulfate D016572 Cyclosporine D003561 Cytarabine D004317 Doxorubicin D004997 Ethinyl Estradiol D016912 Levonorgestrel more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 9.65 RPKM in Testis Total median expression: 86.50 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-44.90	83	-0.541	Picture	PostScript	Text
3' UTR	-304.00	1247	-0.244	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000648 - Oxysterol-bd
IPR018494 - Oxysterol-bd_CS
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology

Pfam Domains:
PF00169 - PH domain
PF01237 - Oxysterol-binding protein
PF15409 - Pleckstrin homology domain

SCOP Domains:
50729 - PH domain-like
144000 - Oxysterol-binding protein-like

ModBase Predicted Comparative 3D Structure on Q9BXB5


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0001786 phosphatidylserine binding GO:0005548 phospholipid transporter activity GO:0008289 lipid binding GO:0015485 cholesterol binding Biological Process: GO:0006629 lipid metabolic process GO:0006869 lipid transport GO:0015914 phospholipid transport GO:0036150 phosphatidylserine acyl-chain remodeling Cellular Component: GO:0005737 cytoplasm GO:0005829 cytosol GO:0005856 cytoskeleton

Descriptions from all associated GenBank mRNAs


	AL833247 - Homo sapiens mRNA; cDNA DKFZp761C0720 (from clone DKFZp761C0720). AB209872 - Homo sapiens mRNA for oxysterol-binding protein-like protein 10 variant protein. AK000370 - Homo sapiens cDNA FLJ20363 fis, clone HEP17001. BC003168 - Homo sapiens oxysterol binding protein-like 10, mRNA (cDNA clone MGC:4401 IMAGE:2905981), complete cds. AF392451 - Homo sapiens oxysterol-binding protein-like protein OSBPL10 (OSBPL10) mRNA, complete cds. LF384603 - JP 2014500723-A/192106: Polycomb-Associated Non-Coding RNAs. AK304067 - Homo sapiens cDNA FLJ58351 complete cds, moderately similar to Oxysterol-binding protein-related protein 10. AK097503 - Homo sapiens cDNA FLJ40184 fis, clone TESTI2018462, highly similar to Oxysterol-binding protein-related protein 10. AF346291 - Homo sapiens OSBP related protein 10 mRNA, partial cds. MA620180 - JP 2018138019-A/192106: Polycomb-Associated Non-Coding RNAs. AL389943 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 2005779. JD424592 - Sequence 405616 from Patent EP1572962. JD506401 - Sequence 487425 from Patent EP1572962. JD162338 - Sequence 143362 from Patent EP1572962. JD294516 - Sequence 275540 from Patent EP1572962. JD239235 - Sequence 220259 from Patent EP1572962. JD313414 - Sequence 294438 from Patent EP1572962. JD334230 - Sequence 315254 from Patent EP1572962. JD160105 - Sequence 141129 from Patent EP1572962. JD058641 - Sequence 39665 from Patent EP1572962. JD443826 - Sequence 424850 from Patent EP1572962. JD309318 - Sequence 290342 from Patent EP1572962. JD427932 - Sequence 408956 from Patent EP1572962. JD309317 - Sequence 290341 from Patent EP1572962. JD274214 - Sequence 255238 from Patent EP1572962. JD180393 - Sequence 161417 from Patent EP1572962. JD056436 - Sequence 37460 from Patent EP1572962. JD309475 - Sequence 290499 from Patent EP1572962. JD069271 - Sequence 50295 from Patent EP1572962. JD395740 - Sequence 376764 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9BXB5 (Reactome details) participates in the following event(s): R-HSA-8867876 OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane R-HSA-1482801 Acyl chain remodelling of PS R-HSA-1483206 Glycerophospholipid biosynthesis R-HSA-1483257 Phospholipid metabolism R-HSA-556833 Metabolism of lipids R-HSA-1430728 Metabolism

Other Names for This Gene


	Alternate Gene Symbols: B4E212, ENST00000396556.1, ENST00000396556.2, ENST00000396556.3, ENST00000396556.4, ENST00000396556.5, ENST00000396556.6, NM_017784, ORP10, OSB10_HUMAN, OSBP9, Q9BTU5, Q9BXB5, uc318yie.1, uc318yie.2 UCSC ID: ENST00000396556.7_10 RefSeq Accession: NM_017784.5 Protein: Q9BXB5 (aka OSB10_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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