ID:P2RX2_HUMAN DESCRIPTION: RecName: Full=P2X purinoceptor 2; Short=P2X2; AltName: Full=ATP receptor; AltName: Full=Purinergic receptor; FUNCTION: Binding of this ligand-gated ion channel to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. SUBUNIT: Functional P2XRs are organized as homomeric and heteromeric trimers. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the P2X receptor family. WEB RESOURCE: Name=Wikipedia; Note=P2X receptor entry; URL="http://en.wikipedia.org/wiki/P2X_receptor";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UBL9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001614 purinergic nucleotide receptor activity GO:0004931 extracellular ATP-gated cation channel activity GO:0005216 ion channel activity GO:0005524 ATP binding GO:0015276 ligand-gated ion channel activity GO:0042802 identical protein binding
Biological Process: GO:0001666 response to hypoxia GO:0003029 detection of hypoxic conditions in blood by carotid body chemoreceptor signaling GO:0006811 ion transport GO:0007268 chemical synaptic transmission GO:0007274 neuromuscular synaptic transmission GO:0007528 neuromuscular junction development GO:0007596 blood coagulation GO:0007605 sensory perception of sound GO:0009743 response to carbohydrate GO:0010033 response to organic substance GO:0010524 positive regulation of calcium ion transport into cytosol GO:0014832 urinary bladder smooth muscle contraction GO:0030432 peristalsis GO:0033198 response to ATP GO:0035590 purinergic nucleotide receptor signaling pathway GO:0048266 behavioral response to pain GO:0048741 skeletal muscle fiber development GO:0050850 positive regulation of calcium-mediated signaling GO:0050909 sensory perception of taste GO:0051260 protein homooligomerization GO:0060079 excitatory postsynaptic potential GO:0098655 cation transmembrane transport
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
