ID:PANX1_HUMAN DESCRIPTION: RecName: Full=Pannexin-1; FUNCTION: Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. SUBUNIT: Homohexamer. Forms homomeric or PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (Potential). Cell junction, gap junction. Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). SIMILARITY: Belongs to the pannexin family. WEB RESOURCE: Name=Wikipedia; Note=Pannexin entry; URL="http://en.wikipedia.org/wiki/Pannexin";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96RD7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002931 response to ischemia GO:0006811 ion transport GO:0006812 cation transport GO:0006816 calcium ion transport GO:0007267 cell-cell signaling GO:0033198 response to ATP GO:0034214 protein hexamerization GO:0050715 positive regulation of cytokine secretion GO:0050717 positive regulation of interleukin-1 alpha secretion GO:0050718 positive regulation of interleukin-1 beta secretion GO:0055085 transmembrane transport GO:0070588 calcium ion transmembrane transport
AF086184 - Homo sapiens full length insert cDNA clone ZC30C07. DL491746 - Novel nucleic acids. DL490326 - Novel nucleic acids. BC016931 - Homo sapiens pannexin 1, mRNA (cDNA clone MGC:21309 IMAGE:4390851), complete cds. AF398509 - Homo sapiens pannexin 1 (PANX1) mRNA, complete cds. JD462319 - Sequence 443343 from Patent EP1572962. AK313074 - Homo sapiens cDNA, FLJ93555. AK074897 - Homo sapiens cDNA FLJ90416 fis, clone NT2RP3000169, highly similar to Pannexin 1. AF093239 - Homo sapiens MRS1 mRNA, complete cds. JD406991 - Sequence 388015 from Patent EP1572962. JD389874 - Sequence 370898 from Patent EP1572962. JD124843 - Sequence 105867 from Patent EP1572962. AY359023 - Homo sapiens clone DNA98600 PANX1 (UNQ2529) mRNA, complete cds. JD462919 - Sequence 443943 from Patent EP1572962. KJ898543 - Synthetic construct Homo sapiens clone ccsbBroadEn_07937 PANX1 gene, encodes complete protein. FM201789 - Homo sapiens mRNA for pannexin 1 (PANX1 gene), cell line THP1. DQ586003 - Homo sapiens piRNA piR-53115, complete sequence. JD460598 - Sequence 441622 from Patent EP1572962. JD350685 - Sequence 331709 from Patent EP1572962. JD303902 - Sequence 284926 from Patent EP1572962. JD224463 - Sequence 205487 from Patent EP1572962. JD359170 - Sequence 340194 from Patent EP1572962. JD553935 - Sequence 534959 from Patent EP1572962. JD244597 - Sequence 225621 from Patent EP1572962. JD289667 - Sequence 270691 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q96RD7 (Reactome details) participates in the following event(s):
R-HSA-375339 Pannexin 1/Pannexin2 mediated neuronal gap junction communication R-HSA-844456 The NLRP3 inflammasome R-HSA-622312 Inflammasomes R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-112303 Electric Transmission Across Gap Junctions R-HSA-168249 Innate Immune System R-HSA-112307 Transmission across Electrical Synapses R-HSA-168256 Immune System R-HSA-112316 Neuronal System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
