Human Gene PCDH17 (ENST00000377918.8_4) from GENCODE V47lift37
  Description: protocadherin 17 (from RefSeq NM_001040429.3)
Gencode Transcript: ENST00000377918.8_4
Gencode Gene: ENSG00000118946.12_8
Transcript (Including UTRs)
   Position: hg19 chr13:58,205,878-58,303,445 Size: 97,568 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr13:58,206,681-58,299,428 Size: 92,748 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:58,205,878-58,303,445)mRNA (may differ from genome)Protein (1159 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PCD17_HUMAN
DESCRIPTION: RecName: Full=Protocadherin-17; AltName: Full=Protocadherin-68; Flags: Precursor;
FUNCTION: Potential calcium-dependent cell-adhesion protein.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (By similarity).
DEVELOPMENTAL STAGE: During midgestation, enriched in the frontal and anterior temporal cortices. Expressed at high levels in the exterior margins of the thalamus, ventromedial striatal neuroepithelium and anterior cingulate.
SIMILARITY: Contains 6 cadherin domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.42 RPKM in Spleen
Total median expression: 98.02 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -278.70803-0.347 Picture PostScript Text
3' UTR -941.504017-0.234 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002126 - Cadherin
IPR015919 - Cadherin-like
IPR020894 - Cadherin_CS
IPR013164 - Cadherin_N

Pfam Domains:
PF00028 - Cadherin domain
PF08266 - Cadherin-like

SCOP Domains:
49313 - Cadherin-like
82051 - Obg GTP-binding protein N-terminal domain

ModBase Predicted Comparative 3D Structure on O14917
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0005515 protein binding

Biological Process:
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007267 cell-cell signaling
GO:0007416 synapse assembly
GO:0030534 adult behavior
GO:0050805 negative regulation of synaptic transmission
GO:1904071 presynaptic active zone assembly
GO:2000807 regulation of synaptic vesicle clustering

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AF029343 - Homo sapiens protocadherin 68 (PCH68) mRNA, complete cds.
AK289980 - Homo sapiens cDNA FLJ77479 complete cds, highly similar to Homo sapiens protocadherin 17, mRNA.
JD448685 - Sequence 429709 from Patent EP1572962.
JD353225 - Sequence 334249 from Patent EP1572962.
JD287442 - Sequence 268466 from Patent EP1572962.
JD483668 - Sequence 464692 from Patent EP1572962.
JD459514 - Sequence 440538 from Patent EP1572962.
JD521638 - Sequence 502662 from Patent EP1572962.
JD391038 - Sequence 372062 from Patent EP1572962.
JD310203 - Sequence 291227 from Patent EP1572962.
JD430869 - Sequence 411893 from Patent EP1572962.
JD479028 - Sequence 460052 from Patent EP1572962.
JD520265 - Sequence 501289 from Patent EP1572962.
JD139593 - Sequence 120617 from Patent EP1572962.
BC028165 - Homo sapiens protocadherin 17, mRNA (cDNA clone MGC:39854 IMAGE:5245587), complete cds.
AK307545 - Homo sapiens cDNA, FLJ97493.
JD438411 - Sequence 419435 from Patent EP1572962.
JD165654 - Sequence 146678 from Patent EP1572962.
JD420024 - Sequence 401048 from Patent EP1572962.
JD109523 - Sequence 90547 from Patent EP1572962.
JD160018 - Sequence 141042 from Patent EP1572962.
JD446495 - Sequence 427519 from Patent EP1572962.
JD390407 - Sequence 371431 from Patent EP1572962.
JD292482 - Sequence 273506 from Patent EP1572962.
JD530224 - Sequence 511248 from Patent EP1572962.
JD205806 - Sequence 186830 from Patent EP1572962.
JD336294 - Sequence 317318 from Patent EP1572962.
JD103938 - Sequence 84962 from Patent EP1572962.
JD104906 - Sequence 85930 from Patent EP1572962.
JD518813 - Sequence 499837 from Patent EP1572962.
JD222440 - Sequence 203464 from Patent EP1572962.
JD065486 - Sequence 46510 from Patent EP1572962.
JD465684 - Sequence 446708 from Patent EP1572962.
JD327952 - Sequence 308976 from Patent EP1572962.
JD204938 - Sequence 185962 from Patent EP1572962.
JD309749 - Sequence 290773 from Patent EP1572962.
JD291137 - Sequence 272161 from Patent EP1572962.
JD304208 - Sequence 285232 from Patent EP1572962.
JD037140 - Sequence 18164 from Patent EP1572962.
JD493123 - Sequence 474147 from Patent EP1572962.
AK001134 - Homo sapiens cDNA FLJ10272 fis, clone HEMBB1001117.
JD202643 - Sequence 183667 from Patent EP1572962.
JD501169 - Sequence 482193 from Patent EP1572962.
JD550464 - Sequence 531488 from Patent EP1572962.
JD528386 - Sequence 509410 from Patent EP1572962.
JD287767 - Sequence 268791 from Patent EP1572962.
JD553491 - Sequence 534515 from Patent EP1572962.
JD511888 - Sequence 492912 from Patent EP1572962.
JD100104 - Sequence 81128 from Patent EP1572962.
JD417441 - Sequence 398465 from Patent EP1572962.
JD320552 - Sequence 301576 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K1R5, ENST00000377918.1, ENST00000377918.2, ENST00000377918.3, ENST00000377918.4, ENST00000377918.5, ENST00000377918.6, ENST00000377918.7, NM_001040429, O14917, PCD17_HUMAN, PCDH68, PCH68, Q5VVW9, Q5VVX0, uc318nyg.1, uc318nyg.2
UCSC ID: ENST00000377918.8_4
RefSeq Accession: NM_001040429.3
Protein: O14917 (aka PCD17_HUMAN or PC17_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.