ID:P4K2A_HUMAN DESCRIPTION: RecName: Full=Phosphatidylinositol 4-kinase type 2-alpha; EC=2.7.1.67; AltName: Full=Phosphatidylinositol 4-kinase type II-alpha; FUNCTION: Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity). CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate. SUBUNIT: Associates with the BLOC-1 and the AP-3 complexes; the BLOC-1 complex is required for optimal binding of PI4K2A to the AP-3 complex. Interacts with BLOC1S5 and DTNBP1. SUBCELLULAR LOCATION: Cytoplasm. Membrane (By similarity). Membrane raft. Cell projection, dendrite (By similarity). Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse, synaptosome (By similarity). Mitochondrion (By similarity). Endosome (By similarity). Cytoplasmic vesicle (By similarity). Note=Localized in neuronal cell body. Transported from neuronal cell body to neuron projections in a BLOC-1- and AP- 3-complexes-dependent manner. Enriched in neurite tips and neuron projections in a BLOC-1- and AP-3-complexes-dependent manner (By similarity). Found in subdomains of the plasma membrane termed non-caveolar membrane rafts. TISSUE SPECIFICITY: Widely expressed. Highest expression is observed in kidney, brain, heart, skeletal muscle, and placenta and lowest expression is observed in colon, thymus, and small intestine. SIMILARITY: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. SIMILARITY: Contains 1 PI3K/PI4K domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BTU6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein Q9BTU6 (Reactome details) participates in the following event(s):
R-HSA-1675780 PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane R-HSA-1675974 PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane R-HSA-1676185 PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane R-HSA-1660499 Synthesis of PIPs at the plasma membrane R-HSA-1660516 Synthesis of PIPs at the early endosome membrane R-HSA-1660514 Synthesis of PIPs at the Golgi membrane R-HSA-1483255 PI Metabolism R-HSA-1483257 Phospholipid metabolism R-HSA-556833 Metabolism of lipids R-HSA-1430728 Metabolism
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
