ID:PIBF1_HUMAN DESCRIPTION: RecName: Full=Progesterone-induced-blocking factor 1; FUNCTION: Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect. TISSUE SPECIFICITY: Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus, prostate, ovary, small intestine, and colon. INDUCTION: By progesterone.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 58104 - Methyl-accepting chemotaxis protein (MCP) signaling domain
ModBase Predicted Comparative 3D Structure on Q8WXW3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005136 interleukin-4 receptor binding GO:0005515 protein binding
Biological Process: GO:0002376 immune system process GO:0007080 mitotic metaphase plate congression GO:0031393 negative regulation of prostaglandin biosynthetic process GO:0032695 negative regulation of interleukin-12 production GO:0032733 positive regulation of interleukin-10 production GO:0032815 negative regulation of natural killer cell activation GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein GO:0042976 activation of Janus kinase activity GO:0071539 protein localization to centrosome GO:0090307 mitotic spindle assembly GO:1905515 non-motile cilium assembly
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
