Human Gene POLR2C (ENST00000219252.10_4) from GENCODE V47lift37

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Description: RNA polymerase II subunit C (from RefSeq NM_032940.3)
Gencode Transcript: ENST00000219252.10_4
Gencode Gene: ENSG00000102978.13_8
Transcript (Including UTRs)
Position: hg19 chr16:57,496,591-57,505,921 Size: 9,331 Total Exon Count: 9 Strand: +
Coding Region
Position: hg19 chr16:57,496,637-57,505,031 Size: 8,395 Coding Exon Count: 9

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr16:57,496,591-57,505,921)			mRNA (may differ from genome)		Protein (275 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: POLR2C Diseases sorted by gene-association score: hiv-1 (4)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) C014211 2,3,7,8-tetrachlorodibenzofuran C016403 2,4-dinitrotoluene D000082 Acetaminophen D004147 Dioxins D004997 Ethinyl Estradiol D019833 Genistein D010126 Ozone D012643 Selenium D013749 Tetrachlorodibenzodioxin more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 20.38 RPKM in Pituitary Total median expression: 743.25 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-20.50	46	-0.446	Picture	PostScript	Text
3' UTR	-302.90	890	-0.340	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001514 - DNA-dir_RNA_pol_30-40kDasu_CS
IPR011261 - DNA-dir_RNA_pol_dimersation
IPR011262 - DNA-dir_RNA_pol_insert
IPR009025 - DNA-dir_RNA_pol_RBP11-like
IPR011263 - DNA-dir_RNA_pol_RpoA/D/Rpb3

Pfam Domains:
PF01000 - RNA polymerase Rpb3/RpoA insert domain
PF01193 - RNA polymerase Rpb3/Rpb11 dimerisation domain

SCOP Domains:
56553 - Insert subdomain of RNA polymerase alpha subunit
55257 - RBP11-like subunits of RNA polymerase

ModBase Predicted Comparative 3D Structure on Q6FGR6


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
Gene Details	Gene Details		Gene Details	Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003677 DNA binding GO:0003899 DNA-directed 5'-3' RNA polymerase activity GO:0046983 protein dimerization activity Biological Process: GO:0006351 transcription, DNA-templated Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005737 cytoplasm GO:0005829 cytosol GO:0015630 microtubule cytoskeleton

Descriptions from all associated GenBank mRNAs


	LF208238 - JP 2014500723-A/15741: Polycomb-Associated Non-Coding RNAs. AK295582 - Homo sapiens cDNA FLJ57937 complete cds, highly similar to DNA-directed RNA polymerase II 33 kDa polypeptide (EC 2.7.7.6). BC003159 - Homo sapiens polymerase (RNA) II (DNA directed) polypeptide C, 33kDa, mRNA (cDNA clone MGC:4212 IMAGE:2957867), complete cds. AK300124 - Homo sapiens cDNA FLJ57430 complete cds, highly similar to DNA-directed RNA polymerase II 33 kDa polypeptide (EC 2.7.7.6). AK293112 - Homo sapiens cDNA FLJ76636 complete cds, highly similar to Homo sapiens polymerase (RNA) II (DNA directed) polypeptide C, 33kDa (POLR2C), transcript variant alpha, mRNA. BC028157 - Homo sapiens polymerase (RNA) II (DNA directed) polypeptide C, 33kDa, mRNA (cDNA clone MGC:40083 IMAGE:5240953), complete cds. AJ224144 - Homo sapiens mRNA variant beta for RNA polymerase II subunit 3. AJ224143 - Homo sapiens mRNA variant alfa for RNA polymerase II subunit 3. J05448 - Human RNA polymerase subunit hRPB 33, mRNA. BC000409 - Homo sapiens polymerase (RNA) II (DNA directed) polypeptide C, 33kDa, mRNA (cDNA clone MGC:8577 IMAGE:2960943), complete cds. KJ891843 - Synthetic construct Homo sapiens clone ccsbBroadEn_01237 POLR2C gene, encodes complete protein. AB464040 - Synthetic construct DNA, clone: pF1KB5332, Homo sapiens POLR2C gene for polymerase (RNA) II (DNA directed) polypeptide C, without stop codon, in Flexi system. DQ894586 - Synthetic construct Homo sapiens clone IMAGE:100009046; FLH176663.01L; RZPDo839F12121D polymerase (RNA) II (DNA directed) polypeptide C, 33kDa (POLR2C) gene, encodes complete protein. DQ891411 - Synthetic construct clone IMAGE:100004041; FLH176667.01X; RZPDo839F12122D polymerase (RNA) II (DNA directed) polypeptide C, 33kDa (POLR2C) gene, encodes complete protein. EU176305 - Synthetic construct Homo sapiens clone IMAGE:100006625; FLH264089.01X; RZPDo839C08257D polymerase (RNA) II (DNA directed) polypeptide C, 33kDa (POLR2C) gene, encodes complete protein. KJ897355 - Synthetic construct Homo sapiens clone ccsbBroadEn_06749 POLR2C gene, encodes complete protein. CR542041 - Homo sapiens full open reading frame cDNA clone RZPDo834B0336D for gene POLR2C, polymerase (RNA) II (DNA directed) polypeptide C, 33kDa; complete cds, incl. stopcodon. AF008443 - Homo sapiens RNA polymerase II subunit hRPB33 mRNA, complete cds. LF373736 - JP 2014500723-A/181239: Polycomb-Associated Non-Coding RNAs. LF373740 - JP 2014500723-A/181243: Polycomb-Associated Non-Coding RNAs. LF373741 - JP 2014500723-A/181244: Polycomb-Associated Non-Coding RNAs. DQ601954 - Homo sapiens piRNA piR-40020, complete sequence. LF373742 - JP 2014500723-A/181245: Polycomb-Associated Non-Coding RNAs. LF373743 - JP 2014500723-A/181246: Polycomb-Associated Non-Coding RNAs. JD145323 - Sequence 126347 from Patent EP1572962. JD239578 - Sequence 220602 from Patent EP1572962. JD242360 - Sequence 223384 from Patent EP1572962. JD262626 - Sequence 243650 from Patent EP1572962. JD272761 - Sequence 253785 from Patent EP1572962. JD048723 - Sequence 29747 from Patent EP1572962. JD036951 - Sequence 17975 from Patent EP1572962. JD477366 - Sequence 458390 from Patent EP1572962. JD554636 - Sequence 535660 from Patent EP1572962. JD519228 - Sequence 500252 from Patent EP1572962. JD563672 - Sequence 544696 from Patent EP1572962. JD096758 - Sequence 77782 from Patent EP1572962. JD285079 - Sequence 266103 from Patent EP1572962. JD552109 - Sequence 533133 from Patent EP1572962. LF373744 - JP 2014500723-A/181247: Polycomb-Associated Non-Coding RNAs. JD301733 - Sequence 282757 from Patent EP1572962. MA443815 - JP 2018138019-A/15741: Polycomb-Associated Non-Coding RNAs. MA609313 - JP 2018138019-A/181239: Polycomb-Associated Non-Coding RNAs. MA609317 - JP 2018138019-A/181243: Polycomb-Associated Non-Coding RNAs. MA609318 - JP 2018138019-A/181244: Polycomb-Associated Non-Coding RNAs. MA609319 - JP 2018138019-A/181245: Polycomb-Associated Non-Coding RNAs. MA609320 - JP 2018138019-A/181246: Polycomb-Associated Non-Coding RNAs. MA609321 - JP 2018138019-A/181247: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000219252.1, ENST00000219252.2, ENST00000219252.3, ENST00000219252.4, ENST00000219252.5, ENST00000219252.6, ENST00000219252.7, ENST00000219252.8, ENST00000219252.9, hCG_2025883 , NM_032940, POLR2C , Q6FGR6, Q6FGR6_HUMAN, uc317cwu.1, uc317cwu.2 UCSC ID: ENST00000219252.10_4 RefSeq Accession: NM_032940.3 Protein: Q6FGR6

Gene Model Information


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Methods, Credits, and Use Restrictions


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