Human Gene POTEF (ENST00000361163.8_5) from GENCODE V47lift37
  Description: Belongs to the POTE family. (from UniProt A6NC16)
Gencode Transcript: ENST00000361163.8_5
Gencode Gene: ENSG00000196604.13_10
Transcript (Including UTRs)
   Position: hg19 chr2:130,864,034-130,878,440 Size: 14,407 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr2:130,864,122-130,878,088 Size: 13,967 Coding Exon Count: 7 

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RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:130,864,034-130,878,440)mRNA (may differ from genome)Protein (382 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsHGNCMalacards
MGIPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: A6NC16_HUMAN
DESCRIPTION: SubName: Full=POTE ankyrin domain family member F;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: POTEF
Diseases sorted by gene-association score: baraitser-winter syndrome (2)

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.93 RPKM in Testis
Total median expression: 1.02 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -130.40352-0.370 Picture PostScript Text
3' UTR -19.5088-0.222 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom

Pfam Domains:
PF00023 - Ankyrin repeat
PF12796 - Ankyrin repeats (3 copies)
PF13606 - Ankyrin repeat
PF13637 - Ankyrin repeats (many copies)
PF13857 - Ankyrin repeats (many copies)

SCOP Domains:
140860 - Pseudo ankyrin repeat-like
48403 - Ankyrin repeat

ModBase Predicted Comparative 3D Structure on A6NC16
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  EF523384 - Homo sapiens POTE-2 alpha-actin mRNA, complete cds.
DQ590292 - Homo sapiens piRNA piR-57404, complete sequence.
JD504529 - Sequence 485553 from Patent EP1572962.
DQ585623 - Homo sapiens piRNA piR-52735, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NC16, A6NC16_HUMAN, EF523384, ENST00000361163.1, ENST00000361163.2, ENST00000361163.3, ENST00000361163.4, ENST00000361163.5, ENST00000361163.6, ENST00000361163.7, POTEF , uc318bxf.1
UCSC ID: ENST00000361163.8_5
RefSeq Accession: NM_001099771.2
Protein: A6NC16

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.