ID:PO3F3_HUMAN DESCRIPTION: RecName: Full=POU domain, class 3, transcription factor 3; AltName: Full=Brain-specific homeobox/POU domain protein 1; Short=Brain-1; Short=Brn-1; AltName: Full=Octamer-binding protein 8; Short=Oct-8; AltName: Full=Octamer-binding transcription factor 8; Short=OTF-8; FUNCTION: Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity). SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Brain. SIMILARITY: Belongs to the POU transcription factor family. Class- 3 subfamily. SIMILARITY: Contains 1 homeobox DNA-binding domain. SIMILARITY: Contains 1 POU-specific domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P20264
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0043565 sequence-specific DNA binding GO:0071837 HMG box domain binding
Biological Process: GO:0001822 kidney development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0007399 nervous system development GO:0007417 central nervous system development GO:0007420 brain development GO:0007588 excretion GO:0008284 positive regulation of cell proliferation GO:0010628 positive regulation of gene expression GO:0021799 cerebral cortex radially oriented cell migration GO:0021869 forebrain ventricular zone progenitor cell division GO:0043066 negative regulation of apoptotic process GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048878 chemical homeostasis GO:0072218 metanephric ascending thin limb development GO:0072227 metanephric macula densa development GO:0072233 metanephric thick ascending limb development GO:0072236 metanephric loop of Henle development GO:0072240 metanephric DCT cell differentiation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
