Human Gene PRDM15 (ENST00000398548.6_10) from GENCODE V47lift37

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Description: PR/SET domain 15, transcript variant 7 (from RefSeq NR_135464.2)
Gencode Transcript: ENST00000398548.6_10
Gencode Gene: ENSG00000141956.14_13
Transcript (Including UTRs)
Position: hg19 chr21:43,218,385-43,299,453 Size: 81,069 Total Exon Count: 24 Strand: -
Coding Region
Position: hg19 chr21:43,221,400-43,280,472 Size: 59,073 Coding Exon Count: 23

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr21:43,218,385-43,299,453)			mRNA (may differ from genome)		Protein (1141 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: PRD15_HUMAN DESCRIPTION: RecName: Full=PR domain zinc finger protein 15; AltName: Full=PR domain-containing protein 15; AltName: Full=Zinc finger protein 298; FUNCTION: May be involved in transcriptional regulation. SUBCELLULAR LOCATION: Nucleus (Potential). SIMILARITY: Contains 16 C2H2-type zinc fingers. SIMILARITY: Contains 1 SET domain. SEQUENCE CAUTION: Sequence=AAL60596.1; Type=Erroneous initiation; Sequence=AAM53515.1; Type=Erroneous translation; Note=Erroneous CDS prediction; Sequence=AAM53516.1; Type=Erroneous translation; Note=Erroneous CDS prediction; Sequence=BAA95527.1; Type=Erroneous gene model prediction;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C016403 2,4-dinitrotoluene D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D016604 Aflatoxin B1 D014635 Valproic Acid

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 4.63 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 91.71 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-28.60	84	-0.340	Picture	PostScript	Text
3' UTR	-968.60	3015	-0.321	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001214 - SET_dom
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF12874 - Zinc-finger of C2H2 type
PF13894 - C2H2-type zinc finger
PF13913 - zinc-finger of a C2HC-type

SCOP Domains:
82199 - SET domain
82657 - BolA-like
57667 - beta-beta-alpha zinc fingers
57783 - Zinc beta-ribbon

ModBase Predicted Comparative 3D Structure on P57071


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0008168 methyltransferase activity GO:0016740 transferase activity GO:0046872 metal ion binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0032259 methylation Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm GO:0016604 nuclear body

Descriptions from all associated GenBank mRNAs


	BC067102 - Homo sapiens PR domain containing 15, mRNA (cDNA clone MGC:71480 IMAGE:5925140), complete cds. AB051812 - Homo sapiens mRNA for zinc finger protein ZNF298a, complete cds. AB051813 - Homo sapiens mRNA for zinc finger protein ZNF298b, complete cds. AB051814 - Homo sapiens mRNA for zinc finger protein ZNF298c, complete cds. AB051815 - Homo sapiens mRNA for zinc finger protein ZNF298d, complete cds. AY078498 - Homo sapiens zinc finger 298 mRNA, complete cds. KJ903045 - Synthetic construct Homo sapiens clone ccsbBroadEn_12439 PRDM15 gene, encodes complete protein. BC032305 - Homo sapiens cDNA clone IMAGE:5181414, ** WARNING: chimeric clone **. AF276513 - Homo sapiens PR-domain zinc finger protein 15 (PRDM15) mRNA, partial cds. AL355710 - Homo sapiens EST from clone 112590, full insert. AL109788 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 814590. AF426259 - Homo sapiens putative C21orf83B protein form A (C21orf83) mRNA, complete cds. AF426260 - Homo sapiens putative C21orf83B protein form B (C21orf83) mRNA, complete cds. AY063456 - Homo sapiens C21orf83 isoform C (C21orf83) mRNA, complete cds. AK123273 - Homo sapiens cDNA FLJ41279 fis, clone BRAMY2037328. JD281336 - Sequence 262360 from Patent EP1572962. JD172932 - Sequence 153956 from Patent EP1572962. JD478910 - Sequence 459934 from Patent EP1572962. JD109944 - Sequence 90968 from Patent EP1572962. AF086532 - Homo sapiens full length insert cDNA clone ZE06E01. JD259492 - Sequence 240516 from Patent EP1572962. JD219693 - Sequence 200717 from Patent EP1572962. JD470426 - Sequence 451450 from Patent EP1572962. JD233543 - Sequence 214567 from Patent EP1572962. JD533663 - Sequence 514687 from Patent EP1572962. JD250264 - Sequence 231288 from Patent EP1572962. JD098675 - Sequence 79699 from Patent EP1572962. JD374261 - Sequence 355285 from Patent EP1572962. JD080713 - Sequence 61737 from Patent EP1572962. JD476081 - Sequence 457105 from Patent EP1572962. JD374778 - Sequence 355802 from Patent EP1572962. JD085990 - Sequence 67014 from Patent EP1572962. JD235309 - Sequence 216333 from Patent EP1572962. JD060581 - Sequence 41605 from Patent EP1572962. AB209162 - Homo sapiens mRNA for PR domain containing 15 variant protein. JD475527 - Sequence 456551 from Patent EP1572962. MP509265 - Sequence 76 from Patent EP3506910.

Other Names for This Gene


	Alternate Gene Symbols: C21orf83 , E9PDJ6, E9PF37, E9PGL3, ENST00000398548.1, ENST00000398548.2, ENST00000398548.3, ENST00000398548.4, ENST00000398548.5, NR_135464, P57071, PRD15_HUMAN, PRDM15 , Q4W8S0, Q4W8S3, Q4W8S4, Q4W8S5, Q8N0X3, Q8NEX0, Q9NQV3, uc318zul.1, uc318zul.2, ZNF298 UCSC ID: ENST00000398548.6_10 RefSeq Accession: NM_001040424.3 Protein: P57071 (aka PRD15_HUMAN or PRDF_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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