ID:ANM8_HUMAN DESCRIPTION: RecName: Full=Protein arginine N-methyltransferase 8; EC=2.1.1.-; AltName: Full=Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4; FUNCTION: Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.3 uM for GRGGFGGRGGFRGGRGG-NH2; SUBUNIT: Homodimers and heterodimers with PRMT1 or PRMT2, recruiting PRMT1 to the cell membrane. Interacts with PRMT2 and FYN (via the SH3 domain). Interacts with EWS; independently of EWS methylation status. INTERACTION: Self; NbExp=3; IntAct=EBI-745545, EBI-745545; SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. TISSUE SPECIFICITY: Brain-specific. DOMAIN: The SH3-binding motifs mediate the interaction with SH3 domain-containing proteins such as PRMT2 and FYN, possibly leading to displace the N-terminal domain and activate the protein. DOMAIN: The N-terminal region (1-60) inhibits the enzymatic activity. SIMILARITY: Belongs to the protein arginine N-methyltransferase family. PRMT8 subfamily. SEQUENCE CAUTION: Sequence=AAF91390.1; Type=Erroneous initiation; Sequence=BAG37987.1; Type=Frameshift; Positions=45;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NR22
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
