ID:PD2R_HUMAN DESCRIPTION: RecName: Full=Prostaglandin D2 receptor; Short=PGD receptor; Short=PGD2 receptor; AltName: Full=Prostanoid DP receptor; FUNCTION: Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (Potential). TISSUE SPECIFICITY: Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes. DISEASE: Genetic variations in PTGDR are associated with susceptibility to asthma-related traits type 1 (ASRT1) [MIM:607277]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/apobec3f/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 53790 - Tetrapyrrole methylase 81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on Q13258
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001785 prostaglandin J receptor activity GO:0004871 signal transducer activity GO:0004930 G-protein coupled receptor activity GO:0004956 prostaglandin D receptor activity GO:0004957 prostaglandin E receptor activity GO:0005515 protein binding
Biological Process: GO:0006954 inflammatory response GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0030238 male sex determination GO:0030431 sleep GO:0046085 adenosine metabolic process GO:0071380 cellular response to prostaglandin E stimulus GO:0071799 cellular response to prostaglandin D stimulus
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
