Human Gene PTGER1 (ENST00000292513.4_7) from GENCODE V47lift37
  Description: prostaglandin E receptor 1 (from RefSeq NM_000955.3)
Gencode Transcript: ENST00000292513.4_7
Gencode Gene: ENSG00000160951.4_9
Transcript (Including UTRs)
   Position: hg19 chr19:14,583,278-14,586,166 Size: 2,889 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr19:14,583,372-14,585,132 Size: 1,761 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:14,583,278-14,586,166)mRNA (may differ from genome)Protein (402 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PE2R1_HUMAN
DESCRIPTION: RecName: Full=Prostaglandin E2 receptor EP1 subtype; Short=PGE receptor EP1 subtype; Short=PGE2 receptor EP1 subtype; AltName: Full=Prostanoid EP1 receptor;
FUNCTION: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.
PTM: Phosphorylated (Potential).
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
SEQUENCE CAUTION: Sequence=BAC05723.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PTGER1
Diseases sorted by gene-association score: tinea barbae (5), antenatal bartter syndrome (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D015232 Dinoprostone
  • C508709 L-335677
  • C092396 17-phenyltrinorprostaglandin E2
  • D015064 16,16-Dimethylprostaglandin E2
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C014024 2,4,5,2',4',5'-hexachlorobiphenyl
  • C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
  • C053876 6-isopropoxy-9-oxoxanthene-2-carboxylic acid
  • D015127 9,10-Dimethyl-1,2-benzanthracene
  • D000643 Ammonium Chloride
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.72 RPKM in Kidney - Cortex
Total median expression: 28.98 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -48.90110-0.445 Picture PostScript Text
3' UTR -35.3094-0.376 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR008365 - Prostanoid_rcpt
IPR001244 - Prostglndn_DP_rcpt
IPR000708 - Prostglndn_EP1_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on P34995
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004955 prostaglandin receptor activity
GO:0004957 prostaglandin E receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0032496 response to lipopolysaccharide

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC039034 - Homo sapiens prostaglandin E receptor 1 (subtype EP1), 42kDa, mRNA (cDNA clone MGC:47749 IMAGE:5748278), complete cds.
BC051286 - Homo sapiens prostaglandin E receptor 1 (subtype EP1), 42kDa, mRNA (cDNA clone MGC:59841 IMAGE:6596880), complete cds.
L22647 - Human prostaglandin receptor ep1 subtype mRNA, complete cds.
JD334696 - Sequence 315720 from Patent EP1572962.
JD131690 - Sequence 112714 from Patent EP1572962.
AY275470 - Homo sapiens prostaglandin E receptor 1 subtype EP1 (PTGER1) mRNA, complete cds.
BC029768 - Homo sapiens prostaglandin E receptor 1 (subtype EP1), 42kDa, mRNA (cDNA clone IMAGE:5184887), partial cds.
JD458891 - Sequence 439915 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_plcePathway - Phospholipase C-epsilon pathway
h_eicosanoidPathway - Eicosanoid Metabolism

Reactome (by CSHL, EBI, and GO)

Protein P34995 (Reactome details) participates in the following event(s):

R-HSA-391936 EP1 receptor can bind PGE2
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-391908 Prostanoid ligand receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-391903 Eicosanoid ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000292513.1, ENST00000292513.2, ENST00000292513.3, NM_000955, P34995, PE2R1_HUMAN, Q5U5U4, Q86UH3, Q86VB5, Q8NHB2, uc317lbj.1, uc317lbj.2
UCSC ID: ENST00000292513.4_7
RefSeq Accession: NM_000955.3
Protein: P34995 (aka PE2R1_HUMAN or PE21_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.