Human Gene PTPN18 (ENST00000175756.10_4) from GENCODE V47lift37

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Description: protein tyrosine phosphatase non-receptor type 18, transcript variant 1 (from RefSeq NM_014369.4)
Gencode Transcript: ENST00000175756.10_4
Gencode Gene: ENSG00000072135.13_10
Transcript (Including UTRs)
Position: hg19 chr2:131,113,629-131,132,978 Size: 19,350 Total Exon Count: 15 Strand: +
Coding Region
Position: hg19 chr2:131,113,681-131,130,797 Size: 17,117 Coding Exon Count: 15

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:131,113,629-131,132,978)			mRNA (may differ from genome)		Protein (460 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: PTN18_HUMAN DESCRIPTION: RecName: Full=Tyrosine-protein phosphatase non-receptor type 18; EC=3.1.3.48; AltName: Full=Brain-derived phosphatase; FUNCTION: Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. SUBUNIT: Interacts with PSTPIP1 (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). TISSUE SPECIFICITY: Expressed in brain, colon and several tumor- derived cell lines. SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene D013749 Tetrachlorodibenzodioxin D000082 Acetaminophen D016604 Aflatoxin B1 D000643 Ammonium Chloride D019256 Cadmium Chloride D002794 Choline D003993 Dibutyl Phthalate D004041 Dietary Fats D004958 Estradiol more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 59.02 RPKM in Spleen Total median expression: 882.58 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-27.60	52	-0.531	Picture	PostScript	Text
3' UTR	-726.70	2181	-0.333	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000387 - Tyr/Dual-specificity_Pase
IPR016130 - Tyr_Pase_AS
IPR000242 - Tyr_Pase_rcpt/non-rcpt

Pfam Domains:
PF00102 - Protein-tyrosine phosphatase

SCOP Domains:
52799 - (Phosphotyrosine protein) phosphatases II

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2OC3 - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q99952


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004721 phosphoprotein phosphatase activity GO:0004725 protein tyrosine phosphatase activity GO:0004726 non-membrane spanning protein tyrosine phosphatase activity GO:0005515 protein binding GO:0016787 hydrolase activity GO:0016791 phosphatase activity Biological Process: GO:0006470 protein dephosphorylation GO:0016311 dephosphorylation GO:0035335 peptidyl-tyrosine dephosphorylation GO:0038128 ERBB2 signaling pathway GO:0071345 cellular response to cytokine stimulus GO:1901185 negative regulation of ERBB signaling pathway Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005737 cytoplasm GO:0005829 cytosol

Descriptions from all associated GenBank mRNAs


	BC031076 - Homo sapiens protein tyrosine phosphatase, non-receptor type 18 (brain-derived), mRNA (cDNA clone IMAGE:5277075). BC024280 - Homo sapiens, Similar to protein tyrosine phosphatase, non-receptor type 18 (brain-derived), clone IMAGE:5088248, mRNA, partial cds. BC041562 - Homo sapiens, Similar to protein tyrosine phosphatase, non-receptor type 18 (brain-derived), clone IMAGE:5921071, mRNA, partial cds. BC052800 - Homo sapiens protein tyrosine phosphatase, non-receptor type 18 (brain-derived), mRNA (cDNA clone MGC:59686 IMAGE:5809095), complete cds. X79568 - H.sapiens BDP1 mRNA for protein-tyrosine-phosphatase. AK303804 - Homo sapiens cDNA FLJ51446 complete cds, highly similar to Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48). JD124995 - Sequence 106019 from Patent EP1572962. KJ902432 - Synthetic construct Homo sapiens clone ccsbBroadEn_11826 PTPN18 gene, encodes complete protein. CU690934 - Synthetic construct Homo sapiens gateway clone IMAGE:100022407 5' read PTPN18 mRNA. AK297884 - Homo sapiens cDNA FLJ59661 complete cds, highly similar to Tyrosine-protein phosphatase non-receptortype 18 (EC 3.1.3.48). AK311140 - Homo sapiens cDNA, FLJ18182. JD455805 - Sequence 436829 from Patent EP1572962. JD109537 - Sequence 90561 from Patent EP1572962. JD102960 - Sequence 83984 from Patent EP1572962. JD235673 - Sequence 216697 from Patent EP1572962. JD498795 - Sequence 479819 from Patent EP1572962. JD265449 - Sequence 246473 from Patent EP1572962. JD486513 - Sequence 467537 from Patent EP1572962. JD497990 - Sequence 479014 from Patent EP1572962. JD103863 - Sequence 84887 from Patent EP1572962. JD174569 - Sequence 155593 from Patent EP1572962. JD058651 - Sequence 39675 from Patent EP1572962. JD237056 - Sequence 218080 from Patent EP1572962. JD503639 - Sequence 484663 from Patent EP1572962. JD103088 - Sequence 84112 from Patent EP1572962. JD438054 - Sequence 419078 from Patent EP1572962. JD331263 - Sequence 312287 from Patent EP1572962. JD332122 - Sequence 313146 from Patent EP1572962. JD181418 - Sequence 162442 from Patent EP1572962. JD084791 - Sequence 65815 from Patent EP1572962. JD383690 - Sequence 364714 from Patent EP1572962. JD069342 - Sequence 50366 from Patent EP1572962. JD054649 - Sequence 35673 from Patent EP1572962. JD070929 - Sequence 51953 from Patent EP1572962. JD399666 - Sequence 380690 from Patent EP1572962. JD088543 - Sequence 69567 from Patent EP1572962. JD501741 - Sequence 482765 from Patent EP1572962. JD293140 - Sequence 274164 from Patent EP1572962. JD356588 - Sequence 337612 from Patent EP1572962. JD506297 - Sequence 487321 from Patent EP1572962. JD374353 - Sequence 355377 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q99952 (Reactome details) participates in the following event(s): R-HSA-8864105 PTPN18 binds ERBB2:EGFR heterodimers R-HSA-8864125 PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 R-HSA-8863795 Downregulation of ERBB2 signaling R-HSA-1227986 Signaling by ERBB2 R-HSA-9008059 Interleukin-37 signaling R-HSA-9006934 Signaling by Receptor Tyrosine Kinases R-HSA-446652 Interleukin-1 family signaling R-HSA-162582 Signal Transduction R-HSA-449147 Signaling by Interleukins R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168256 Immune System

Other Names for This Gene


	Alternate Gene Symbols: B4E1E6, BDP1, ENST00000175756.1, ENST00000175756.2, ENST00000175756.3, ENST00000175756.4, ENST00000175756.5, ENST00000175756.6, ENST00000175756.7, ENST00000175756.8, ENST00000175756.9, NM_014369, PTN18_HUMAN, Q53P42, Q99952, uc317cep.1, uc317cep.2 UCSC ID: ENST00000175756.10_4 RefSeq Accession: NM_014369.4 Protein: Q99952 (aka PTN18_HUMAN or PTNI_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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