ID:ARIP4_HUMAN DESCRIPTION: RecName: Full=Helicase ARIP4; EC=3.6.4.12; AltName: Full=Androgen receptor-interacting protein 4; AltName: Full=RAD54-like protein 2; FUNCTION: DNA helicase that modulates androgen receptor (AR)- dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity). CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. ENZYME REGULATION: Enzyme activity is enhanced by dsDNA (double- stranded DNA) and ssDNA (single-stranded DNA) (By similarity). SUBUNIT: Interacts with AR via its N-terminus. Interacts with DYRK1A. Binds DNA and mononucleosomes, but does not seem to form large multiprotein complexes (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Localizes in speckle-like nuclear compartments (By similarity). DOMAIN: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to be important for the association with nuclear receptors (By similarity). PTM: Sumoylated (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the SNF2/RAD54 helicase family. SIMILARITY: Contains 1 helicase ATP-binding domain. SIMILARITY: Contains 1 helicase C-terminal domain. SEQUENCE CAUTION: Sequence=AAH24298.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y4B4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
