ID:RBP10_HUMAN DESCRIPTION: RecName: Full=Ran-binding protein 10; Short=RanBP10; FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen- induced transactivation. In contrast to RANBP9, does not interact with Sos and does not activate the Ras pathway. SUBUNIT: May form homodimers. Interacts with RAN and RANBP9. Interacts with the HGF receptor MET. Interacts with AR. Interacts with TUBB1. May interact with TUBB5 (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytosol. Nucleus. Note=Predominantly cytoplasmic. TISSUE SPECIFICITY: Broadly expressed, with highest levels in skeletal muscle. DOMAIN: The SPRY domain mediates the interaction with MET (By similarity). SIMILARITY: Belongs to the RANBP9/10 family. SIMILARITY: Contains 1 B30.2/SPRY domain. SIMILARITY: Contains 1 CTLH domain. SIMILARITY: Contains 1 LisH domain. SEQUENCE CAUTION: Sequence=BAA95988.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6VN20
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
