ID:RIPL1_HUMAN DESCRIPTION: RecName: Full=RILP-like protein 1; AltName: Full=Rab-interacting lysosomal-like protein 1; FUNCTION: Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution. SUBUNIT: Interacts (when S-nitrosylated) with GAPDH (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytosol. TISSUE SPECIFICITY: Widely expressed. Expressed at lower level in liver and kidney. PTM: S-nitrosylation is required for the interaction with GAPDH (By similarity). SIMILARITY: Belongs to the RILPL family. SIMILARITY: Contains 1 RILP-like domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5EBL4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0031267 small GTPase binding GO:0046983 protein dimerization activity GO:0051959 dynein light intermediate chain binding
Biological Process: GO:0003382 epithelial cell morphogenesis GO:0015031 protein transport GO:0060271 cilium assembly GO:1901214 regulation of neuron death GO:1903445 protein transport from ciliary membrane to plasma membrane
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
