ID:R144A_HUMAN DESCRIPTION: RecName: Full=Probable E3 ubiquitin-protein ligase RNF144A; EC=6.3.2.-; AltName: Full=RING finger protein 144A; AltName: Full=UbcM4-interacting protein 4; AltName: Full=Ubiquitin-conjugating enzyme 7-interacting protein 4; FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with UBE2L3. SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). SIMILARITY: Belongs to the RBR family. RNF144 subfamily. SIMILARITY: Contains 1 IBR-type zinc finger. SIMILARITY: Contains 2 RING-type zinc fingers. CAUTION: Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family. SEQUENCE CAUTION: Sequence=BAA11478.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P50876
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004842 ubiquitin-protein transferase activity GO:0016740 transferase activity GO:0031624 ubiquitin conjugating enzyme binding GO:0046872 metal ion binding GO:0061630 ubiquitin protein ligase activity
Biological Process: GO:0000209 protein polyubiquitination GO:0016567 protein ubiquitination GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
